With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.887590-25-2,tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate,as a common compound, the synthetic route is as follows.
887590-25-2, A partial solution of tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate (100 mg, 0.467 mmol), 1,3-dibromobenzene (220 mg, 0.933 mmol), C52CO3 (608 mg, 1.867 mmol) in toluene (1 mL), was purged and degassed with N2, then 2,2?- bis(diphenylphosphino)-1,1?-binaphthalene (58.1 mg, 0.093 mmol) and palladium(II) acetate (20.95 mg, 0.093 mmol) were added, and the vessel was purged and degassedagain. The reaction flask was capped and stirred at 110 C overnight. The mixture was cooled, water (15 mL) was added and extracted with ethyl acetate (15 mL x 3). The combined organic layers were washed with brine, dried over Na2504, and concentrated. The residue was purified on silica gel with a gradient of 0-100% EtOAc in hexanes to give tert-butyl 4-(3 -bromophenyl)-3 ,4-dihydroquinoxaline- 1 (2H)-carboxylate (120 mg66.1% yield) as a white solid. LCMS M = 389.10/391.15. Method G. Retention time4.175 mm.
The synthetic route of 887590-25-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; BATT, Douglas G.; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; LIU, Qingjie; MARCOUX, David; NEELS, James; POSS, Michael A.; QIN, Lan-ying; RUAN, Zheming; SHI, Qing; SRIVASTAVA, Anurag S.; TINO, Joseph A.; WATTERSON, Scott Hunter; (532 pag.)WO2016/64957; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider