55687-02-0,55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Pd(Ph3P)4 (28.5 mg, 0.025 mmol) was added to a degassed solution of 6- bromo-2-chloroquinoxaline (60 mg, 0.246 mmol), (lR,3S,5R)-tert-butyl 3-(6-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-benzo[d]imidazol-2-yl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (1 15 mg, 0.271 mmol) and sodium bicarbonate (62.1 mg, 0.739 mmol) in dioxane (1 mL) and FLO (0.2 mL) and the mixture was stirred at 1 10 C for 2 h and then at 120 C for 2 h. The reaction was diluted with MeOH, filtered and purified by prep HPLC (H20-MeOH with lOmM NH4OAc buffer) to yield (lR,3S,5R)-tert-butyl 3-(6-(6-bromoquinoxalin-2-yl)-lH-benzo[d]imidazol-2-yl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (102.2 mg, 0.202 mmol, 82 % yield) as bright yellow solid. LC-MS retention time 2.31 min; m/z 506 [M+H] . (ColumnPHENOMENEX Luna 3.0 x 50mm S 10. Solvent A = 90% water: 10% methanol: 0.1% TFA. Solvent B = 10% water:90% methanol: 0.1% TFA. Flow Rate = 4 mL/min. Start % B = 0. Final % B = 100. Gradient Time = 3 min. Wavelength = 220).
The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen; WO2011/59850; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider