108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Sodium hydride (349 mg, 0.008792 mol, 1.2 eq) was added to a solution of 2-ethylbutyl 2-cyanoacetate (1.23 g, 0.007326 mol, 1.00 eq) in dry DMF (20 ml) at 0C under inert atmosphere. After 10 minutes, 2,3-dichloroquinoxaline (1.75 g, 0.008792 mol, 1.2 eq) was added and the reacting mixture was stirred overnight at 70C. The solution was cooled to 0C then diluted in sat. H4CI and extracted with DCM . The combined organic layers were dried over MgS0 , filtered and concentrated. Purification by column chromatography on silica gel (0 to 30% AcOEi/liexanes) provided 2-ethylbutyi 2-(3-chloroquinoxalin-2-yl)-2-cyanoacetate as a yellow solid (2.20 g, 74% yield). A solution of (Z)-2-ethylbutyl 2-(3-chloroquinoxalin-2(lH)-ylidene)-2-cyanoacetate (1 eq), piperazine (3 eq) and DIPEA (3 eq) in methanol (0.1M) was stirred at 120C in a microwave for 90 minutes or until completion. The solution was cooled down, diluted in water/DCM followed by extraction with DCM. The combined organic layers were dried over MgS04, filtered, concentrated and purified by column chromatography on silica gel (0 to 100% AcOEt in hexanes) or by reverse phase C18 (5 to 100% CH3CN 0.1% TFA in water 0.1% TFA) to furnish (Z)-2-ethylbutyl 2-cyano-2-(3-(piperazin-l-yl)quinoxalin-2(lH)-ylidene)acetate., 108229-82-9
As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.
Reference£º
Patent; CORSELLO, Steven M.; GOLUB, Todd R.; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; STEFAN, Eric; HILGRAF, Robert; (158 pag.)WO2018/183936; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider