With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
To a suspension of the quinoxaline-2-carboxylate (542 mg, 3.13 mmol) in methanol (20 ml) is added 28% aqueous ammonia (1.5 ml), and the mixture is refluxed for 3 hours. Water is added to the residue obtained by distilling off solvent under reduced pressure and the precipitate is collected by filtration. After air-drying, these are dissolved into ethyl acetate, which is dried over anhydrous sodium sulfate. Solvent is removed by distillation, and the residue is decanted with isopropyl ether and air-dried to give the title compound (369 mg; yield 76%)., 879-65-2
The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRUM THERAPEUTICS PTY. LTD.; WO2006/110477; (2006); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider