50998-17-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
To a solution of 11c (50 mg, 215 mumol), 6-bromoquinoxaline (66.9 mg, 320 mumol), Bu4NOAc (129 mg, 428 mumol) and Pd(OAc)2 (7.24 mg, 32.2 mumol) in NMP (0.5 mL ). The reaction mixture was stirred for 15 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water, and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12c (17 mg, 22%) as a yellow solid. TLC: Rf 0.22 (1:1 MeOH/CH2Cl2). 1H-NMR (400 MHz, CDCl3) delta 8.90 (d, 2H, J = 4.4 Hz), 8.09 (s, 1H), 8.08 (d, 1H, J = 8.0 Hz), 7.73 (t, 1H, J = 8.0 Hz), 7.63-7.60 (m, 2H), 7.13 (d, 1H, J = 8.0 Hz), 3.65 (t, 2H, J = 6.4 Hz), 2.85 (t, 2H, J = 7.6 Hz), 2.20 (s, 3H), 1.88 (quintet, 2H, J = 7.6 Hz), 1.65 (m, 2H), 1.58 (brs, 1H). 13C-NMR (100 MHz, CDCl3) delta 158.3, 149.2, 147.3, 145.8, 145.7, 142.8, 142.7, 139.1, 132.8; 132.1, 130.9, 130.4, 129.2, 123.6, 115.2, 62.4, 32.3, 25.7, 24.7, 23.8. HRMS (ESI) calcd. for C20H21N6O (M+H): 361.1771; found 361.1771.
As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.
Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider