Day: October 20, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

[001023] Part C. Preparation of 6-bromo-2-chloroquinoxaline.; [001024] To a flask containing phosphorus oxychloride (3.4ml, 36.5mmol) was added the product fromPart B (255mg, l.lmmol) and the solution was heated at 6O0C overnight. The solution was cooled to room temperature, poured over ice and the resulting solid collected by filtration to give the title compound (239mg, 87%).

55687-34-8, The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6639-87-8,6-Nitroquinoxaline,as a common compound, the synthetic route is as follows.

2. 1,2,3,4-tetrahydro-5-amino-6-nitroquinoxaline 5-Amino-6-nitroquinoxaline was synthesised by reaction of 6-nitroquinoxaline with hydroxylamine in an alkaline medium in accordance with J. Chem. Soc., Perkin I, 1975, 1229. The product was reacted With sodium borohydride as in Example 1). The 1,2,3,4-tetrahydro-5-amino-6-nitroquinoxaline obtained in the form of brown crystals in a yield of 11.5% of the theoretical had a melting point of 213 C., 6639-87-8

6639-87-8 6-Nitroquinoxaline 96029, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Henkel Kommanditgesellschaft auf Aktien; US5089025; (1992); A;,
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89891-65-6, 7-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of intermediate 431 ( 1 00 mg, 0.41 mmol) in dioxane (4 niL) and Nu.Eta2Omicron(10 mL, 25%) was stirred in a sealed tube at 1 10C overnight. The mixture was concentrated to give the crude intermediate 432 (108 mg) as a yellow solid., 89891-65-6

The synthetic route of 89891-65-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; WU, Tongfei; BREHMER, Dirk; BEKE, Lijs; BOECKX, An; DIELS, Gaston, Stanislas, Marcella; GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph; LAWSON, Edward, Charles; PANDE, Vineet; PARADE, Marcus, Cornelis, Bernardus, Catharina; SCHEPENS, Wim, Bert, Griet; THURING, Johannes, Wilhelmus, John, F; VIELLEVOYE, Marcel; SUN, Weimei; MEERPOEL, Lieven; (375 pag.)WO2017/32840; (2017); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution OF 4- [ (4-BROMOPHENYL) (ethoxyimino) methyl]-1- (4-methyl-4- piperidinyl) piperidine (100 mg, 0.24 MMOL), 3-hydroxy-2-quinoxalinecarboxylic acid (56 mg, 0.29 MMOL) and ET3N (87 mg, 0.86 MMOL) in DMF (6 mL), HATU (119 mg, 0.31 MMOL) was added at room temperature and the reaction was stirred for 24h. The reaction mixture was poured into ice water and the first crop of solid was collected by filtration. The water layer was extracted with ethyl acetate and the organic layer was washed with NAHC03, dried and concentrated to give the second crop of solid. The two crops of crude were combined and purified by flash chromatography (2% to 10%, MEOH/CH2CI2) to afford the title compound as an orange solid. MS 579 (M+).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/113323; (2004); A1;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6925-00-4, (2S)-3-Phenyl-2-[(1-quinoxalin-6-ylmethanoyl)amino]propionic acid, t-butyl ester: Quinoxaline-6-carboxylic acid (2b, 2.57 g, 14.8 mmol) is dissolved in anhydrous dichloromethane (75 mL) and N,N-diethyl-isopropylamine (2.83 mL, 16.2 mmol) under argon in a flask equipped with stir bar and septum. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.11 g, 16.2 mmol) is added and allowed to stir 10 minutes before 1-hydroxybenzotriazole hydrate (2.19 g, 16.2 mmol) is added. After another 5 minutes, L-phenylalanine t-butyl ester hydrochloride (3.80 g, 14.8 mmol) is added and the mixture is allowed to stir at room temperature overnight. The reaction mixture is diluted with dichloromethane (100 mL) and washed with saturated sodium bicarbonate solution (1*100 mL), water (1*100 mL), and brine (1*100 mL). The organic layer is dried over MgSO4 and concentrated to a brown foam which is applied to a column of silica gel in dichloromethane and eluted with 2% methanol/dichloromethane. Concentration of the appropriate fractions gives 4.4 g (79%) of the desired product as a very thick oil.

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Procter & Gamble Company; US2004/6104; (2004); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3476-89-9,1,2,3,4-Tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.

24d. 1-Methyl-4-(2-nitro-phenyl)-1,2,3,4-tetrahydro-quinoxaline To a solution of 1,2,3,4-tetrahydroquinoxaline (60 mg, 0.403 mmol) in DMSO (2 mL) was add potassium tert-butoxide (91 mg, 0.81 mmol), followed by 2-fluoro-nitrobenzene (57 mg, 0.403 mmol). The reaction mixture was stirred at 80 C. for 16 h. The desired product was isolated via silica gel chromatography using 0% to 50% EtOAc in hexane as eluding solvent to afford 24d (49 mg, 45%) as radish foam. LC-MS ESI m/z 270 [M+H]+., 3476-89-9

As the paragraph descriping shows that 3476-89-9 is playing an increasingly important role.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.82019-32-7,7-Bromo-1-methyl-1H-quinoxalin-2-one,as a common compound, the synthetic route is as follows.

Bis(neopentyl glycolato)diboron (1.42 mg, 6.30 mmol) and potassium acetate (823 mg, 8.40 mmol) were added to a solution of 7-bromo-1-methylquinoxalin-2(1H)-one (1.0 g, 4.2 mmol) in 1,4-dioxane (15 mL). The reaction mixture was degassed under nitrogen for 30 min before Pd(dppf)Cl2.DCM (171 mg, 0.21 mmol) was added. The reaction mixture was heated at 80 C. for 3 h. After this time the reaction mixture was concentrated under reduced pressure and purified by silica gel column chromatography eluting with 30% EtOAc in iso-hexane to afford an orange solid. Trituration with diethyl ether afforded the title compound as an off-white solid (340 mg, 30%). 1H NMR (400 MHz, CDCl3): delta 8.37-8.30 (m, 1H), 7.79 (m, 3H), 3.82 (s, 4H), 3.75 (s, 3H), 1.06 (s, 6H)., 82019-32-7

The synthetic route of 82019-32-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; LONN, Hans Roland; CONNOLLY, Stephen; SWALLOW, Steven; KARLSSON, Staffan PO; AURELL, Carl-Johan; PONTEN, John Fritiof; DOYLE, Kevin James; VAN DE POEL, Amanda Jane; JONES, Graham Peter; WATSON, David Wyn; MACRITCHIE, Jaqueline Anne; PALMER, Nicholas John; US2015/210655; (2015); A1;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6925-00-4

In a [11 3] neck flask was placed Quinoxaline-6-carboxylic acid (20.2 g) in 500 ml of THF. To this solution was slowly added [THIONYLCHLOLIDE] [(42ML,] [5EQ.).] The reaction mechanically stirred was warmed up to reflux and followed by HPLC quenching the sample with NH40H. After 3h at reflux no more starting material was present, the solvent was removed under reduced pressure and [SOC12] was chased with toluene 3 times. The solid was suspended in 100 ml EtOAc and filtered to obtain 23.47g of a beige solid. HPLC : 1. [114MIN. IHNMR] (DMSO-d6) [69.] 01-7.40 (m, [5H).]

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2004/7491; (2004); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

6924-66-9, Example 25To a 50 mL flask containing 20 mL of DMF was added 1 mL of oxalyi chloride slowly and stirred for 10 min at RT. 100 mg of quinoxaline-5-carboxyltc acid was dissolved in 2 mL of the above solution and stirred for 5 min at RT. Then 50 mg of E was dissolved in 1 mL pyridine and added to the above solution. The reaction was completed in 5 min at RT and quenched with 1 mL NH4OH. The solvent was then evaporated under vacuum and the residue dissolved in CH3CN and water and purified with prep HPLC (0% to 95% water/ Acetonitriie) to afford 25 (26.7 mg, 54%). 1H-NMR (DMSO, 300 MHz): delta 9.04-9.02 (m, 2H), 8.49 (d, J = 3.9 Hz, 1 H), 8.31 (d, J = 6.0 Hz, 1 H), 8.24 (d, J = 8.4 Hz, 1 H), 7.94 (t, J – 7.2 Hz, 1 H), 7.73 (d, J = 6.9 Hz, 1 H), 7.62-7.57 (m, 2H), 7.22 (t, J = 8.4 Hz, 1 H), 7.06 (t, J = 6.6 Hz, 1 H)1 6.98 (d, J = 7.8 Hz, 2H), 6.80 (d, J = 7.5 Hz, 1 H), 4.83 (me, 1 H), 3.18-3.06 (m, 3H), 2.77-2.75 (m, 1 H), 0.65 (m, 2H), 0.51 (m, 2H).LCMS m/z [M+Hj+ C32H25N5O3S requires: 560.64. Found 560.08 HPLC Tr (min), purity %: 3.36, 98%

6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; GILEAD SCIENCES, INC.; MACKMAN, Richard, L.; SPERANDIO, David; YANG, Hai; WO2011/5842; (2011); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

6925-00-4, Example 12-(1,2-Dimethyl-3-oxo-5-quinoxalin-6-yl-2,3-dihydro-1H-pyrazol-4-yl)-benzonitrileStep 1A: Quinoxaline-6-carboxylic acid methoxy-methyl-amideA 2000 mL round bottomed flask was charged with 21.0 g (121 mmoles) of quinoxaline-6-carboxylic acid, 32.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (169 mmoles), 22.8 g of 1-hydroxybenzotriazole (169 mmoles), and 24.7 g of N,O-dimethylhydroxylamine hydrochloride (253 mmoles) under a nitrogen atmosphere. To this, 315 mL of tetrahydrofuran and 210 mL of dichloromethane were added. Next, 127 mL of triethylamine (729 mmoles) was charged, and the reaction was allowed to stir for 12 hours. After the reaction was complete, the contents of the flask were concentrated to 1/3 volume under vacuum, and 440 mL of water was added. The mixture was extracted with ethyl acetate (3¡Á200 mL); the subsequent organic fractions were then washed with saturated sodium bicarbonate (1¡Á200 mL) and dried over sodium sulfate. The final product (26.1 g; 99% yield) was obtained after removing the solvent under vacuum. The product was used without further purification.1H NMR 300 MHz (CDCl3) delta 3.35 (s, 3H), 3.49 (s, 3H), 7.97 (d, J=8.7 Hz, 1H), 8.05 (d, J=8.7 Hz, 1H), 8.36 (s, 1H), 8.81 (s, 1H).M/Z Theoretical: 217.09; M/Z+1 217.77.

6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Biogen Idec MA Inc.; US2010/56505; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider