6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6925-00-4, (2S)-3-Phenyl-2-[(1-quinoxalin-6-ylmethanoyl)amino]propionic acid, t-butyl ester: Quinoxaline-6-carboxylic acid (2b, 2.57 g, 14.8 mmol) is dissolved in anhydrous dichloromethane (75 mL) and N,N-diethyl-isopropylamine (2.83 mL, 16.2 mmol) under argon in a flask equipped with stir bar and septum. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.11 g, 16.2 mmol) is added and allowed to stir 10 minutes before 1-hydroxybenzotriazole hydrate (2.19 g, 16.2 mmol) is added. After another 5 minutes, L-phenylalanine t-butyl ester hydrochloride (3.80 g, 14.8 mmol) is added and the mixture is allowed to stir at room temperature overnight. The reaction mixture is diluted with dichloromethane (100 mL) and washed with saturated sodium bicarbonate solution (1*100 mL), water (1*100 mL), and brine (1*100 mL). The organic layer is dried over MgSO4 and concentrated to a brown foam which is applied to a column of silica gel in dichloromethane and eluted with 2% methanol/dichloromethane. Concentration of the appropriate fractions gives 4.4 g (79%) of the desired product as a very thick oil.
The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; The Procter & Gamble Company; US2004/6104; (2004); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider