With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
879-65-2, EXAMPLE 3 Preparation of quinoxaline-2-carboxylic acid {2-(3-fluoro-phenyl)-1-[4-(3-hydroxy-3-methyl-butyl)-5-oxo-tetrahydro-furan-2-yl]-ethyl}-amide (IIa1-3) 2-Quinoxaline acid (3.05 g, 1.2 eq) and carbonyl diimidazole (2.72 g, 1.15 eq) were heated in anhydrous THF (30 ml) under nitrogen for 2 h.An aliquot was taken and derivatized quickly with pyrrolidine in acetonitrile (HPLC assay should show complete anhydride formation, on scale, 2-quinoxaline acid will be refluxed in THF first, and atmospherically strip off some THF to ensure complete dryness).The mixture was then cooled, and added via a cannula to the amine (IIIa1-2) (4.5 g, crude oil from example 2) solution [note: no exotherm observed].The reaction was stirred for 1 h at room temperature, and assay showed no starting material left.The reaction was quenched with water (50 ml).The layers were separated, and the organic phase was washed with 10% NaHCO3 (50 ml) once, and concentrated to give an oil under vacuum. The oil was water wet, but directly used in the next step. 9.58 (s, 1H), 8.05-8.18 (m, 3H), 7.85-7.88 (m, 2H), 7.81-7.27 (m, 3H), 4.58-4.65 (m, 1H), 3.02-3.20 (m, 1H), 2.44-2.61 (m, 1H), 2.34-2.38 (m, 1H), 1.95-2.08 (m, 1H), 1.76-1.98 (m, 1H), 1.38-1.61 (m, 6H), 1.15 (s, 6H).
The synthetic route of 879-65-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pfizer Inc.; US2004/19217; (2004); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider