With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1865-11-8,Methyl quinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: In a round bottom flask, the previously prepared methyl ester 2 (2 g, 10.6 mmol) was stirred in ethanol (50 mL) in the presence of cesium carbonate (0.3 g, 0.92 mmol) at ambient temperature. The progress of the reaction was followed by GC chromatography. At the end of the transesterification, the reaction mixture was evaporated to dryness and the product was extracted with dichloromethane (425 mL). The combined organic layers were then dried over MgSO4 and, after filtration, evaporated to dryness. The ethyl ester 3 was obtained as beige powder. Yield: 67percent., 1865-11-8
As the paragraph descriping shows that 1865-11-8 is playing an increasingly important role.
Reference£º
Article; Maj, Anna M.; Heyte, Svetlana; Araque, Marcia; Dumeignil, Franck; Paul, Sebastien; Suisse, Isabelle; Agbossou-Niedercorn, Francine; Tetrahedron; vol. 72; 10; (2016); p. 1375 – 1380;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider