1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (69.6 mg, 0.360 mmol) and 1-hydroxybenzotriazole monohydrate (55.6 mg, 0.360 mmol) were added to a methylene chloride solution (3.0 ml) of the resulting compound (100 mg, 0.300 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (57.5 mg, 0.300 mmol), at room temperature, under nitrogen stream, followed by further addition of N-methylmorpholine (0.170 ml, 1.50 mmol), and stirring was carried out at room temperature overnight. The reaction solution was poured into a 2N aqueous hydrochloric acid solution, followed by extraction with ethyl acetate and sequential washing with water, a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Biotage, Inc., 25+M), the residue resulting from concentration was suspended in a mixed solvent of methylene chloride-diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (59.1 mg, yield 44%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.9 (1H, brs), 9.70 (1H, brs), 7.88 (1H, dd, J=7.8 Hz, 4.6 Hz), 7.65 (1H, dt, J=7.8 Hz, 1.0 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38(1H, d, J=7.8 Hz), 7.13 (2H, m), 7.03 (2H, m), 5.02 (1H, m), 4.60 (1H, m), 4.02-3.19 (4H, m), 2.06-1.85 (2H, m), 1.72-1.44 (2H, m), 1.31 (3H, d, J=6.6 Hz). IR (KBr) cm-1: 2935, 1685, 1640, 1505, 1205. MS (ESI, m/z): 439 (M+H)+. HRMS (ESI, m/z): 439.1791 (Calcd for C23H24FN4O4: 439.1782)., 1204-75-7
1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
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