32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 2-chloro-3-methylquinoxaline (89 mg, 0.50 mmol, 1 equiv), N-Boc-2- pyrroleboronic acid (158 mg, 0.75 mmol, 1.5 equiv), and K3P045H20 (0.45 g, 1.5 mmol, 3 equiv) was added THF (400 iL) then a THF stock solution of 3 and PAd3 (100 .iL, 0.25 imol of Pd/PAd3). The mixture was stirred at 70 C for 5 h. The reaction mixture was diluted with ethylacetate then extracted with water. The combine organic layers were evaporated and the crude product was purified by flash chromatography. After drying, 148 mg (96 %) of 30 was obtained as a white solid.1H NMR (501 MHz, CDC13) 8.09 – 7.98 (m, 2H), 7.74 – 7.63 (m, 2H), 7.43 (dd, J 3.4, 1.7 Hz, 1H), 6.44 (dd, J= 3.3, 1.7 Hz, 1H), 6.33 (t, J= 3.4 Hz, 1H), 2.56 (s, 3H), 1.17 (s, 9H).3C{1H} NMR (126 MHz, CDC13) oe 154.5, 149.6, 148.6, 141.2, 140.3, 130.7, 129.8, 129.1,129.0, 128.3, 122.5, 115.6, 111.4, 84.2, 27.4, 23.0.HRIVIS (ESI) mlz calculated for C18H19N302 (M+1) 310.1550, found 310.1552., 32601-86-8
32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; THE TRUSTEES OF PRINCETON UNIVERSITY; CARROW, Brad P.; CHEN, Liye; (51 pag.)WO2017/75581; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider