With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
879-65-2, EXAMPLE 8 Preparation of 5-chloro-7-[2-(pyridin-2-yl)ethyl]-2-(quinoxalin-2-yl)-benzoxazole This is prepared from 2-amino-4-chloro-6-[2-(pyridin-2-yl)ethyl]phenol and 2-quinoxaline carboxylic acid using method B to give the intermediate amide (32%). This is cyclised with methanesulphonic acid in toluene with azeotropic removal of water with a Dean-Stark trap to give the title compound as a white crystalline solid (9%), m.p 182-183 C. TLC (SiO2, EtOAc:hexanes 1:1, Rf=0.27). Mass spectrum CI (methane) m/z=387 [M+H]+.
879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Euro-Celtique, S.A.; US6166041; (2000); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider