Analyzing the synthesis route of 6298-37-9

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, To a solution of 8-methyl-2-phenylquinoline-3-carboxaldehyde (80 mg, 0.32 mmol) in THF (5 mL) was added di-w-butyltin dichloride (10 mg, 0.032 mmol), phenylsilane (70 mg, 0.64 mmol) and 6-aminoquinoxaline (46 mg, 0.32 mmol). The mixture was heated in a microwave at 1000C for 3 h. Purification by preparative HPLC {Method 2) gave the title compound as an off-white solid (45 mg, 37%). deltaH (CDCl3) 8.61 (d, J2.1 Hz, IH), 8.51 (d, J 1.9 Hz, IH), 8.24 (s, IH), 7.84 (d, J9.0 Hz, IH), 7.71-7.76 (m, IH), 7.61-7.66 (m, IH), 7.40-7.58 (m, 6H), 7.10 (dd, J9.2, 2.6 Hz, IH), 6.88 (d, J2.6 Hz, IH), 4.64-4.69 (m, 2H), 4.52-4.60 (m, IH), 2.82 (s, 3H). LCMS (ES+) 377.2 (M+H)+, RT 4.23 minutes {Method 4).

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; WO2009/81105; (2009); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider