With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.
108229-82-9, To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), hydrazine hydrate90% (0.07 mL, 1.5 mmol) was added and the reaction mixture was stirred in an ice bath at 0 C for 2 h.After completion of the reaction, the precipitate that formed was filtered, dried and the crude productwas further purified by a silica gel column chromatography (chloroform) to give the product. Yield:61%; (red-brown powder): mp 201-203 C; IR (KBr) max in cm1: 3415, 3250, 3146 (NH2, NH), 1598(C=N); 1H-NMR (DMSO-d6): 5.00 (s, br, 2H, NH2; exchangeable with D2O), 7.37-7.79 (m, 3H, Ar-H),9.16 (s, br, 1H, NH; exchangeable with D2O); 13C-NMR (DMSO-d6): 124.68, 129.67, 130.02, 134.78,138.98, 140.60 (6Ar-C), 145.22, 145.85, (2C=N); MS (m/z), 64 (M+ C4H4BrClN3; 100%), 272 (M+; 5%),273 (M+ + 1; 21%), 274 (M+ + 2; 17%), 275 (M+ + 3; 3%), 276 (M+ + 4; 5%). Anal. Calcd. for C8H6BrClN4(273.52): C, 35.13; H, 2.21; N, 20.48%. Found: C, 34.97; H, 2.45; N, 20.34%.
The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider