With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-05-3,2,5-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.
EXAMPLE 2 Preparation of 4-N’,N’-dimethylamino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide A suspension of sodium hydride (60%, 114 mg, 2.85 mmol) in N,N-dimethylformamide (10 ml) under nitrogen at room temperature was treated with p-dimethylaminobenzenesulfonamide (214 mg, 1.07 mmol), and after stirring one hour, solid 2,5-dichloroquinoxaline (231 mg, 1.16 mmol) was added. After stirring overnight, the reaction mixture was poured into water (100 ml) and the pH adjusted to 3-4 by the addition of 1N hydrochloric acid solution. The resulting precipitate was collected, dried and purified by silica gel flash chromatography (EtOAc/hexanes/THF) to yield the title product (56 mg, 14%) as a solid. Analysis of the title compound gave the following results: 1 H NMR (300 MHz, d6 -DMSO)delta2.92(s, 6H, CH3), 6.72 (d, 2H, J=7.8 Hz, Ar-H), 7.68-7.84 (overlapping multiplets, 3H, Ar-H), 7.85 (d, 2H, J=8.0 Hz, Ar-H), 8.61 (s, 1H, Ar-H), 11.78(s, 1H, exchanges with D2 O, NH); IR(KBr) 1600, 1582, 3.448, 1148 and 1089 cm-1; FDMS(DMSO) m/e=362, 364 (M+). Analysis of C16 H15 ClN4 O2 S: Theory: C, 52.96; H, 4.17; N, 15.44. Found: C, 53.17; H, 4.30; N, 15.30., 55687-05-3
55687-05-3 2,5-Dichloroquinoxaline 10679487, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Eli Lilly and Company; US5529999; (1996); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider