With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.473932-16-0,2-(Quinoxalin-6-yl)acetic acid,as a common compound, the synthetic route is as follows.
Trimethylsilyldiazomethane [2.0M in hexanes] (0.08?xL) was added dropwise to a solution of quinoxalin-6-yl-acetic acid (0.030g, 0.159mmol) in toluene/methanol [8/1] (0.5mL) and stirred until the bubbling stopped. The reaction was then evaporated and the crude product was purified via silica gel column chromatography in hexane: ethyl acetate (1:1) to give 0.013g of quinoxaJin-6-yl-acetic acid methyl ester. This was added to a solution of hydrazine (O.lOinL) in methanol and stirred at room temperature overnight. The reaction mixture was evaporated in vacuo to give 0.019g of quinoxalin-6-yl-acetic acid hydrazide. 1H NMR (400 MHz, DMSO-d6) 8 9.77 (bs, IH), 9.35 (m, 2H), 8.46 (d, IH, J=8.8Hz), 8.39 (m, IH), 8.19 (dd, IH, J=2.0, 8.8Hz), 4.68 (bs, 2H), 4.07 (s, 2H).
473932-16-0, The synthetic route of 473932-16-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/75567; (2007); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider