Day: November 6, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

A mixture of N- (4- (methylsulfonyl) benzyl) -3, 4-dihydro-2H- 1 , 4-benzoxazine-7-carboxamide (0.028 g, 0.08 mmol) , 6- bromoquinoxaline (33 mg, 0.160 mmol), RuPhos Pd Gl (5.83 mg, 8.00 mumol), RuPhos (3.73 mg, 8.00 muetaalphaomicron) , NaOtBu (0.023 g, 0.240 mmol) and D E (1 mL) was heated at 130 C for 2 h under (3825) microwave irradiation. The reaction mixture was diluted with AcOEt (3 mL) and quenched with H20 (1 mL) , and stirred for 2 min. The organic layer was separated and then the aqueous layer was extracted with EtOAc (2 mL) . The combined organic layer was evaporated by blowing away with the air at 60 C. The residue was purified by preparative HPLC (Actus Triart C18, eluted with MeCN/10 itiM NH4HCO3 aq. 5:95?100:0). Pure fractions were combined and concentrated by blowing away with the air at 60C to afford the title compound (18.3 mg, 0.0368 mmol, 48%)., 50998-17-9

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMAMOTO, Satoshi; SHIRAI, Junya; KONO, Mitsunori; SHIOKAWA, Zenyu; YUKAWA, Tomoya; IMADA, Takashi; NEGORO, Nobuyuki; ODA, Tsuneo; SASAKI, Satoshi; NARA, Yoshi; SUZUKI, Shinkichi; SATO, Ayumu; ISHII, Naoki; SHIBUYA, Akito; NAKAGAWA, Yasuo; COLE, Derek; GIBSON, Tony; IVETAC, Anthony; SWANN, Steve; TYHONAS, John; (472 pag.)WO2018/30550; (2018); A1;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To an oven-dried one-arm round bottom flask were added 6-bromoquinoxaline (10b) (216 mg,1.00 mmol), Pd(PPh3)2Cl2 (14.3 mg, 20.0 mumol), CuI (19.5 mg, 100 mumol) and anhydrous THF(2 mL) under argon atmosphere. The solution was bubbled with argon gas for 7 min to remove the dissolved gases. Then, trimethylsilylethyne (537 muL, 3.80 mmol) and Et3N (893 muL, 6.41mmol) were added sequentially, and the reaction mixture was stirred at rt for 14 h. Upon completion of the reaction, the reaction mixture was diluted with EtOAc (10 mL) and washed with water (2 ¡Á 7 mL) and brine (7 mL). The organic layer was dried over anhydrous MgSO4,filtered, and concentrated by rotary evaporation. Purification by column chromatography (10:1hexanes/EtOAc) yielded 11b (110 mg, 49%) as a brown solid., 50998-17-9

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Jeong, Yunkyung; Lee, Jooyeon; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry; vol. 24; 9; (2016); p. 2114 – 2124;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

Under the protection of nitrogen,Add 3-methyl-2-chloro-quinoxaline (1.78 g, 10 mmol) to a solution of 2-benzylaminoethoxyethanol (9.76 g, 50 mmol) in N-methylpyrrolidone (100 mL).Heated to 190 C reflux for 15 h,The reaction was monitored by LC-MS, and the reaction was completed. The reaction mixture was cooled, and ice water was added to the reaction mixture, which was extracted with ethyl acetate (50 mL*3), and the organic mixed phase was washed with water (100 mL) and saturated brine (100 mL*2) Dry over anhydrous sodium sulfate, filter, decompress the solvent under reduced pressure, and then purified by chromatography on silica gel column.Drying in vacuo gave 2.58 g of white solid compound VIII-2.Yield: 76.8%,, 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Patent; Chengdu Yuandong Bio-pharmaceutical Co., Ltd.; Zhang Tao; Zeng Yanqun; Yan Shengyong; Wang Ying; (22 pag.)CN108774183; (2018); A;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-chloro-3-methylquinoxaline (350 mg, 1.96 mmol), 2-amino-1-(piperidin-1-yl)ethanone hydrochloride (445 mg, 2.49 mmol) and DIPEA (1.027 mL, 5.88 mmol) in acetonitrile (4.0 mL) was heated to 100 C for 40 h. The reaction mixture was concentrated and dissolved in ethyl acetate (15 mL) and water (20 mL). The organic layer was separated. The aqueous layer was washed with ethyl acetate (5 x 15 mL). The organic layers were combined, dried through a hydrophobic frit and concentrated in vacuo. The crude material was purified using silica chromatography with a gradient of 0-70 % (3:1 ethylacetate:ethanol + 1 % triethylamine)/cyclohexane. The relevant fractions were combined and concentratedin vacuo to yield 2-((3-methylquinoxalin-2-yl)amino)-1-(piperidin-1-yl)ethanone (182 mg, 0.640 mmol, 32 % yield) as a brown powder. LCMS (High pH, ES+): tR = 0.96 min, [M+H]+ 285.19. 1H NMR (400 MHz, CDCl3) delta 1.59-1.75 (m, 6H), 2.64 (s, 3H), 3.47-3.53 (m, 2H), 3.63-3.69 (m, 2H), 4.33 (d, J = 3.79 Hz, 2H), 6.26 (br. s., 1H), 7.36 (ddd, J = 8.15, 7.01, 1.26 Hz, 1H), 7.51 (ddd, J = 8.27, 7.01,1.39 Hz, 1H), 7.69 (dd, J = 8.34, 1.01 Hz, 1H), 7.83 (dd, J = 8.08, 1.26 Hz, 1H) 13C NMR (101 MHz, CDCl3) delta 20.9, 24.4, 25.5, 26.3, 42.8, 43.3, 45.5, 124.2, 125.7, 128.1, 128.8, 136.9, 141.3, 145.4, 150.2, 166.8 HRMS: (C16H20N4O) [M+H]+ requires 285.1710, found [M+H]+ 285.1702 numax (neat): 3392, 1639, 1582, 1508, 1439, 1253, 1013, 769 cm-1., 32601-86-8

As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.

Reference£º
Article; Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A.; Synthesis; vol. 49; 16; (2017); p. 3775 – 3793;,
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32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8 N,N’-Bis(2-propenyl)carbamimidothioic acid(3-methyl-2-quinoxalinyl)ester, hydrochloride 2-Chloro-3-methylquinoxaline (3.56 g., 0.02 mole) was dissolved in 50 ml. of methanol, treated with Norit and filtered. The filtrate was added to 3.125 g. (0.02 mole) of 1,3-diallylthiourea in 50 ml. of methanol. The mixture was stirred at room temperature for 31/2 hours, then freed of solvent. Acetone was added to the residue and the solution again freed of solvent. The residue was triturated with ether and with acetone, filtered, washed and dried to give 4.12 g. (61.5% yield), m.p. 90-93 C. Analysis for: C16 H19 ClN4 S Calculated: C, 57.39; H, 5.72; N, 16.73; Cl, 10.59. Found: C, 56.99; H, 5.66; N, 16.58; Cl, 10.77.

32601-86-8, The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.

6298-37-9, The first organolithium R3Li (2.5 mmol) is added slowly to a solution of compound D (1 mmol) in anhydrous THF at -78 C. under inert atmosphere of nitrogen. The solution becomes reddish-black. The mixture is stirred at -78 C. for 2.5 h. The mixture is placed at 0 C. and the second organolithium R4Li (2 mmol) is immediately added slowly. The mixture is stirred at 0 C. for 2 h. The reaction is hydrolyzed by a saturated aqueous NH4Cl solution and extracted with ethyl acetate. The organic phase is washed with water saturated with NaCl, dried on anhydrous MgSO4 and concentrated under reduced pressure. The residue obtained is dissolved in CHCl3 (20 ml) and then MnO2 (5 mmol, 430 mg) is added and the mixture carried at reflux for 4 h. The reaction is hydrolyzed and then filtered on celite. The organic phase is dried on anhydrous MgSO4 and concentrated under vacuum. The products are purified on a silica column in a mixture of cyclohexane and ethyl acetate in a proportion of 5:5.Yield: 30%1H NMR (300 MHz, CDCl3) delta ppm: 0.96 (m, 6H); 1.31-1.32 (m, 8H); 1.40-1.52 (m, 2H); 1.68-1.79 (m, 2H); 2.9 (m, 4H); 4.10 (s, 2H); 7.05 (m, 2H); 7.74 (d, J=9.6 Hz, 1H).13C NMR (75 MHz, CDCl3) delta ppm: 13.9, 14.0, 22.5, 29.1, 29.2, 29.3, 29.4, 31.6, 35.1, 35.4, 108.0, 120.5, 129.3, 135.8, 142.5, 146.9, 152.6, 156.6.ESI-MS m/z: 286 ([M+H]+, 40).IR cm-1: 725, 830, 855, 930, 960, 1080, 1135, 1235, 1340, 1465, 1500, 1620, 2925, 2855, 2955, 3215, 3335.

The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); US2011/118270; (2011); A1;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0181] To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) were added HATU (13.3 g, 35 mmol. 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and Omicron,Nu- Dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at rt overnight, then the solvent was concentrated. The residue was purified via flash column (PE/EA = 2/1, v/v) t

6925-00-4, As the paragraph descriping shows that 6925-00-4 is playing an increasingly important role.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/49701; (2013); A1;,
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59564-59-9, 3,4-Dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 80 5-Methyl-4-(1,2,3,4-tetrahydro-3-oxo-1-quinoxalinyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid Methyl Ester Example 27 (23 mg, 0.1 mmol) was stirred with 1,2,3,4-tetrahydroquinoxalin-2-one (44.4 mg, 0.3 mmol) in DMF (0.5 mL) for 1 hr at 50 C. Water was added and the resulting solid material was collected, washed with water and dried. The material was triturated with methanol, filtered, and dried again to provide 20 mg (59%) of a white solid. 1H NMR (d-DMSO): delta 8.30-8.25 (m, 2H), 7.12-7.03 (m, 2H), 6.83 (br s, 2H), 4.38 (s, 2H), 3.73 (s, 3H), 2.49 (s, 3H), 1.72 (s, 3H)., 59564-59-9

59564-59-9 3,4-Dihydroquinoxalin-2(1H)-one 185949, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol Myers Squibb Company; US6982265; (2006); B1;,
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 5,8-dibromoquinoxaline (3) (287 mg, 1.0 mmol), Pd(PPh3)2Cl2 (70 mg, 0.1 mmol), CuI (9.5 mg, 0.05 mmol) and PPh3 (26 mg, 0.1 mmol) in triethylamine/tetrahydrofuran 1:1 (20 mL) was stirred and heating until 70 148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aguiar, Leonardo de O.; Junior, Adalberto S.L.; Bechtold, Ivan H.; Curcio, Sergio Fernando; Cazati, Thiago; Alves, Tiago V.; Vieira, Andre Alexandre; Journal of Molecular Liquids; vol. 296; (2019);,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, vi) [(1R,3R)-3-(3-Chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)-cyclohexyl]-quinoxalin-6-yl- amine: A solution of (1 R,3R)-3-(3-Chloro-phenylethynyl)-3-(4-methoxy-benzyloxy)- cyclohexylamine (34 mg), 6-bromoquinoxaline (23 mg), NaOt-Bu (13 mg), Pd2(dba)3 ‘ CHCI3 (1.9 mg) and BINAP (3.5 mg) in de-gassed toluene (2 ml) was stirred under Ar atmosphere for 1.5 h at 100. The mixture was distributed between cold 1 M Na2CO3 and EtOAc, the phases EPO separated, the aqueous phase ectracted with EtOAc, the combined organic phases dried over Na2SO4 and evaporated. Chromatography afforded 38 mf of the desired product (83%).

The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2006/114260; (2006); A1;,
Quinoxaline – Wikipedia
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