32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-chloro-3-methylquinoxaline (350 mg, 1.96 mmol), 2-amino-1-(piperidin-1-yl)ethanone hydrochloride (445 mg, 2.49 mmol) and DIPEA (1.027 mL, 5.88 mmol) in acetonitrile (4.0 mL) was heated to 100 C for 40 h. The reaction mixture was concentrated and dissolved in ethyl acetate (15 mL) and water (20 mL). The organic layer was separated. The aqueous layer was washed with ethyl acetate (5 x 15 mL). The organic layers were combined, dried through a hydrophobic frit and concentrated in vacuo. The crude material was purified using silica chromatography with a gradient of 0-70 % (3:1 ethylacetate:ethanol + 1 % triethylamine)/cyclohexane. The relevant fractions were combined and concentratedin vacuo to yield 2-((3-methylquinoxalin-2-yl)amino)-1-(piperidin-1-yl)ethanone (182 mg, 0.640 mmol, 32 % yield) as a brown powder. LCMS (High pH, ES+): tR = 0.96 min, [M+H]+ 285.19. 1H NMR (400 MHz, CDCl3) delta 1.59-1.75 (m, 6H), 2.64 (s, 3H), 3.47-3.53 (m, 2H), 3.63-3.69 (m, 2H), 4.33 (d, J = 3.79 Hz, 2H), 6.26 (br. s., 1H), 7.36 (ddd, J = 8.15, 7.01, 1.26 Hz, 1H), 7.51 (ddd, J = 8.27, 7.01,1.39 Hz, 1H), 7.69 (dd, J = 8.34, 1.01 Hz, 1H), 7.83 (dd, J = 8.08, 1.26 Hz, 1H) 13C NMR (101 MHz, CDCl3) delta 20.9, 24.4, 25.5, 26.3, 42.8, 43.3, 45.5, 124.2, 125.7, 128.1, 128.8, 136.9, 141.3, 145.4, 150.2, 166.8 HRMS: (C16H20N4O) [M+H]+ requires 285.1710, found [M+H]+ 285.1702 numax (neat): 3392, 1639, 1582, 1508, 1439, 1253, 1013, 769 cm-1., 32601-86-8
As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.
Reference£º
Article; Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A.; Synthesis; vol. 49; 16; (2017); p. 3775 – 3793;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider