With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.
6298-37-9, General procedure: To a solution of S7 (502.3 mg, 1.4 mmol) in THF (10 mL) containing 10 muL DMF was added oxalylchloride (360.0 muL, 0.3 mmol) at room temperature. The solution was stirred for 2 h andconcentrated. The resulting acid chloride S8 (37.0 mg, 0.1 mmol) was reacted with thecorresponding amine (0.2 mmol) and N,N-Diisopropylethylamine (52.3 muL, 0.3 mmol) overnight.The solution was extracted with ethyl acetate (3 mL), washed with citric acid solution, saturatedNaHCO3, and concentrated. The residue was then purified by preparative TLC.
6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Article; Lee, Hsin-Yu; Suciu, Radu M.; Horning, Benjamin D.; Vinogradova, Ekaterina V.; Ulanovskaya, Olesya A.; Cravatt, Benjamin F.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 16; (2018); p. 2682 – 2687;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider