879-65-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.
5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (32 mg, 0.101 mmol) obtained in Example 1, (3), quinoxaline-2-carboxylic acid (35 mg, 0.202 mmol), and O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (42 mg, 0.111 mmol) were dissolved in DMF (2.0 mL), then the solution was added with triethylamine (20 mg, 0.202 mmol), and the mixture was stirred over night. The reaction mixture was treated in a conventional manner to obtain the title compound (10 mg, yield 21%) as yellow crystals. 1H NMR (CDCl3, 400MHz) delta: 3.63 (2H, s), 7.07 (1H, d, J=9Hz), 7.33 (2H, d, J=9Hz), 7.62 (2H, d, J=8Hz), 7.71 (1H, t, J=8Hz), 7.8-8.0 (5H, m), 8.09 (1H, d, J=8Hz), 8.1-8.3 (2H, m), 8.50 (1H, s), 9.75 (1H, s), 9.91 (1H, s)
As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.
Reference£º
Patent; Nippon Chemiphar Co., Ltd.; USHIODA, Masatoshi; KOBAYASHI, Kunio; SAITO, Daisuke; SAKUMA, Shogo; IMAI, Toshiyasu; INOUE, Kazuhide; EP2803662; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider