Day: November 10, 2020

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

49679-45-0, The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.

49679-45-0, Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder. Mp 233.3 C. 1 H NMR (300 MHz, DMSO-d6) d 10.08 (bs, 1H, NH), 9.52 (bs, 1H, OH), 7.99 (dd, 1H, J 8.4, 0.6 Hz), 7.85e7.75 (m, 2H), 7.61e7.54 (m, 2H), 7.24e7.14 (m, 2H), 6.51 (dd, 1H, J 7.4, 2.4, 1.5 Hz), 4.48 (q, 2H, J 7.2 Hz, CH2), 1.41 (t, 3H, J 7.2 Hz, CH3). 13C NMR (75 MHz, DMSO-d6) d 166.1, 158.3, 148.8, 142.4, 140.7, 136.0, 133.4, 132.7, 130.0 (2 C), 126.7, 126.6, 111.1, 110.6, 107.3, 62.8, 14.5.

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

55687-02-0, In a 10 ml seal tube, methyl (4S,7S)-6,10-dioxo-4-(5-(4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)- 1 H-imidazol-2-yl)octahydro- 1 H-pyridazino [ 1 ,2- a][l,2]diazepin-7-ylcarbamate (240 mg, 459 muiotaetaomicron?) (Intermediate 3), 6-bromo-2- chloroquinoxaline (112 mg, 459 muiotaetaomicron?) and Cs2C03 (299 mg, 917 muiotaetaomicron?) were combined with 1,4-dioxane (3.00 ml) and water (0.5 ml) to give a light brown solution. It was degased for 10 min and tetrakis(triphenylphosphine)palladium (0) (53.0 mg, 45.9 muiotaetaomicron?) was added. The reaction mixture was heated at 80 C for 16 h. It was diluted with EtOAc (6 ml) andconcentrated in vacuo. The residue was purified on a silica gel column (CH2C12, 2%, 3%, 5%, 8% and 10% MeOH/CH2Cl2 ) to afford methyl (4S,7S)-4-(5-(4-(6-bromoquinoxalin-2- yl)phenyl)- 1 H-imidazol-2-yl)-6, 10-dioxooctahydro- 1 H-pyridazino [ 1 ,2-a] [ 1 ,2]diazepin-7- ylcarbamate as a red solid (240 mg, 86.6%). ESI-LRMS m/e calcd for C28H26BrN704 [M+] 604, found 605 [M+H+].

As the paragraph descriping shows that 55687-02-0 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; BRINKMAN, John A.; LI, Hongju; SARABU, Ramakanth; SO, Sung-Sau; WO2013/53657; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.,50998-17-9

EXAMPLE 121fert-Butyl 3-(quinoxalin-6-yl)benzylcarbamate6-Bromoquinoxaline (500 mg, 2.39 mmol), 3-(aminomethyl)phenylboronic acid hydrochloride (445 mg, 2.39 mmol), potassium phosphate (1000 mg, 4.78 mmol), water (3 mL), DME (13 mL) and Pd(PPh3)4 (277 mg, 0.24 mmol) were combined in a sealed tube and heated under microwave irradiation to 1400C for 1 h. Di-tert-butyl dicarbonate (545 mg, 2.50 mmol) was then added and the reaction mixture stirred at room temperature for 18 h. The organic layer was concentrated to dryness and purified by chromatography (SiO2, 20-100% EtOAc in petroleum ether) to give a yellow gum (232 mg). A sample (30 mg) was further purified by preparative HPLC to give the title compound (21.6 mg) as a clear solid. deltaH (CDCl3) 8.88 (IH, d, J 1.85 Hz), 8.85 (IH, d, J 1.86 Hz), 8.31 (IH, d, J 2.05 Hz), 8.18 (IH, d, J 8.73 Hz), 8.05 (IH, dd, J 8.74, 2.08 Hz), 7.67 (2H, d, J6.92 Hz), 7.49 (IH, t, J7.84 Hz), 7.37 (IH, d, J7.61 Hz), 4.93 (IH, s), 4.44 (2H, d, J5.95 Hz), 1.48 (9H, s). LCMS (ES+) 336 (M+H)+, RT 3.58 minutes {Method 2).

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; WO2010/52448; (2010); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.,91-19-0

Bromine (3.84g, 24mmol) was added dropwise to a magnetically stirred refluxing mixture of quinoxaline (1) (390mg, 3.0mmol) and barium carbonate (1.20g, 6.1mmol) in acetonitrile (20mL). The resulting reaction mixture was heated at reflux temperature for 25h and allowed to warm to room temperature. The solvent was evaporated and the mixture was diluted with a saturated solution of sodium carbonate (10mL). The mixture was extracted with ethyl acetate (3¡Á25mL) and combined organic layers were washed with water, dried over Na2SO4 and concentrated. The residue was purified via column chromatography on silica gel (100g) by eluting with 15% EtOAc/n-hexane. The first fraction was 6-bromoquinoxaline (10) (195mg, 31%) data as before. The second fraction was 5,8-dibromoquinoxaline (12) (45mg, 5%) data as before. The third fraction was 6,7-dibromoquinoxaline (13) (50mg, 6%) data as before. The fourth fraction was 5,7-dibromoquinoxaline (11) (120mg, 14%) data as before. The fifth fraction was 5,6-dibromoquinoxaline (14) (240mg, 28%) data as before.

The synthetic route of 91-19-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ucar, Sefa; E?siz, Selcuk; Da?tan, Arif; Tetrahedron; vol. 73; 12; (2017); p. 1618 – 1632;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

0.6 g Iridium (III) chloride hydrate (2 mmol), 0.79 g 5-methyl-5H-benzo[c][1,5]naphthyridin-6-one (4.4 mmol), 24 mL 2-ethoxy ethanol, and 7 mL water were added and reacted for 24 hr under nitrogen. After cooling, filtration, and washing by small amount of methanol, a chlorine-bridged dimer complex was obtained. The complex, 1.06 g sodium carbonate (Na2CO3) (10 mmol), 25 mL 2-ethoxyanol, and 0.7 g quinoxaline-2-carboxylic acid (4 mmol) were then mixed and reacted for 9 hr under nitrogen. After cooling, solid was precipitated and washed by small amount of water. After purification by silicon-gel column, 0.63 g yellow solid was obtained, with a yield of 40%.1H NMR (CDCl3, 400 MHz) spectrum data9.85 (s, 1 H), 8.58 (d, J=5.5 Hz, 1 H), 8.20 (d, J=8.4 Hz, 1 H), 7.93-7.75 (m, 4 H), 7.68 (d, J=8.5 Hz, 1 H), 7.64 (d, J=8.5 Hz, 1 H), 7.47-7.43 (m, 2 H), 7.31-7.15 (m, 3 H), 7.05 (t, J=7.6 Hz, 1 H), 6.76 (d, J=7.4 Hz, 1 H), 6.22 (d, J=7.4 Hz, 1 H), 3.80 (s, 3 H), 3.77 (s, 3 H)., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE; US2008/214818; (2008); A1;,
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7712-28-9, 3-(3-Hydroxyquinoxalin-2-yl)propanoic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7712-28-9, General procedure: In a typical reaction, AMA 2:3 (10mmol), the corresponding carboxylic acid (1mmol) and the alcohol (2ml) were mixed in the provided reaction glass tube equipped with a screw cap and magnetic agitation until a wet mixture was achieved. The reaction mixture was irradiated with microwaves (Anton Parr Monowave 300 reactor) at 120C for 10-25min. On cooling, the mixture was diluted with DCM (41mL), and filtered over celite. Then the filtrate was washed with Na2CO3 (ss) and water. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to give the ester.

As the paragraph descriping shows that 7712-28-9 is playing an increasingly important role.

Reference£º
Article; Estrin, Dario; Fabian, Lucas; Gomez, Natalia; Moglioni, Albertina; Salvatori, Melina; Taverna Porro, Marisa; Turk, Gabriela; European Journal of Medicinal Chemistry; vol. 188; (2020);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.

A suspension of 2,3,6-trichloroquinoxaline (J. Med. Chem. 33, 2240-54,1990) (5.84 g, 25 mmol) in dry methanol (70 ml) was stirred at 50 C. while methanolic sodium methoxide (30 mmol) (prepared from 0.7 g of sodium and 70 ml of dry methanol) was added over 5 hours. After the addition was complete, heating and stirring was continued for a further 16 hours. The mixture was cooled in an ice bath, the precipitate filtered off, washed with a small amount of methanol and dried to afford 4.28 g of a mixture consisting of 2,3-dimethoxy-6-chloroquinoxaline, 2,6-dichloro-3-methoxyquinoxaline and 3,6-dichloro-2-methoxy-quinoxaline, respectively., 2958-87-4

The synthetic route of 2958-87-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novo Nordisk A/S; US6927214; (2005); B1;,
Quinoxaline – Wikipedia
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148231-12-3, 5,8-Dibromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen atmosphere, the compound of formula (F) (1.34 g, 7.26 mmol) 5,8-dibromoquinoxanline (0.951 g, 3.30 mmol), sodium tert-butoxide (0.952 g, 9.90 mmol), Bis (dibenzylideneacetone) palladium (0) (0.114 g), (¡À) -2,2 ‘- (¡À) -2,2′-bis (diphenylphosphino ) -1,1′-binaphthalene [(¡À) -2,2′-Bis (diphenylphosphino) -1,1’-binaphthalene] (0.185 g, 0.297 mmol) was refluxed for 12 hours. After the temperature was lowered to room temperature, the mixture was washed with water, the residue was removed with MgSO 4, hydrazine monohydrate was added thereto, and the mixture was stirred at room temperature for 30 minutes. Precipitated in hexane, filtered off the solid and dried under vacuum to obtain the compound P-1.

148231-12-3, 148231-12-3 5,8-Dibromoquinoxaline 11514763, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; LG Chem, Ltd.; Kim Jin-seok; Bae Jae-sun; Lee Jae-cheol; Shin Hyeon-a; Hwang Min-ho; Ryu So-yeong; Jeong Se-jin; (36 pag.)KR2019/5591; (2019); A;,
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