32601-86-8, 2-Chloro-3-methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-chloro-3-methylquinoxaline L [45] (500mg, 2.8mmol) and 3-trifluoromethylaniline (2,5mL, 20mmol) in anhydrous DMF (10mL) was heated at 140C in a sealed vial under microwave irradiation. After completion of the reaction (45min), CH2Cl2 was added, and the organic phase was washed successively with 1M HCl and brine. The organic layer was then dried with Na2SO4, filtered and evaporated. The resulting solid was purified by silica gel column chromatography (eluent: CH2Cl2) to afford 3-Methyl-N-(3-(trifluoromethyl)phenyl)quinoxalin-2-amine. Yield 69%. Amber powder. mp 98C. 1H NMR (250MHz, CDCl3) delta=8.24 (s, 1H), 7.93 (d, J=8.1 Hz, 1H), 7.87 (dd, J=8.1, 1.1 Hz, 1H), 7.78 (dd, J=8.2, 1.0 Hz, 1H), 7.64-7.53 (m, 1H), 7.52-7.39 (m, 2H), 7.37-7.27 (m, 1H), 6.77 (bs, 1H, NH), 2.65 (s, 3H). 13C NMR (63MHz, CDCl3) delta=147.7, 144.6, 140.3 (d, J=3.2 Hz), 137.9, 131.5 (q, J=33.1 Hz), 129.4 (d, J=6.0 Hz), 128.2, 126.9, 126.1, 124.3 (q, J=272.9 Hz), 122.8, 119.6 (d, J=3.8 Hz), 116.6 (d, J=3.4 Hz), 21.03. LC-MS (ESI, 35 eV): tR=4.75min, m/z 304 [M+H]+., 32601-86-8
The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Desroches, Justine; Kieffer, Charline; Primas, Nicolas; Hutter, Sebastien; Gellis, Armand; El-Kashef, Hussein; Rathelot, Pascal; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 68 – 86;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider