With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3476-89-9,1,2,3,4-Tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.
Example 4: Synthesis of 2- (3, 4-DIHYDRO-2H-QUINOXALIN-1-YLMETHYL)-1, 1, 1-TRIFLUORO-4- (5- fluoro-2-methoxyphenyl)-4-methylpentan-2-ol A solution of 2-[2-(5-FLUORO-2-METHOXYPHENYL)-2-METHYLPROPYL]-2-TRIFLUOROMETHYLOXIRANE (see Example 1) (54.4 mg) and tetrahydroquinoxaline (124. 8 mg) in DMF (0.6 mL) was heated at 100C for 6 hours. The resulting mixture was diluted with diethyl ether, washed with water and brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by preparative TLC (eluted with 25% diethyl ether-benzene) to give the title compound as a clear oil (31.2 mg)., 3476-89-9
The synthetic route of 3476-89-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2004/63163; (2004); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider