With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.
(3) To a solution of 4-chloro-2-(hydroxymethyl)-6-pyrrolidin-1-ylpyrimidine (1.00 g, 4.68 mmol) and 2-chloro-3-methylquinoxaline (1.25 g, 7.02 mmol) in N,N-dimethylformamide (10 mL) and tetrahydrofuran (20 mL) was added sodium hydride (60% dispersion in mineral oil, 281 mg, 7.02 mmol) at 0 C. The reaction mixture was stirred for 2 hour at room temperature, and then poured into cold water. The mixture was extracted with ethyl acetate and the organic layer was washed with water. The organic layer was dried over magnesium sulfate, filtrated and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1 to 7:3) to give 4-chloro-2-{[(3-methylquinoxalin-2-yl)oxy]methyl}-6-pyrrolidin-1-ylpyrimidine as red powder (1.67 g, quant.). mp 136-140 C. MS (APCI): m/z 356/358 (M+H).
32601-86-8, The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Kawanishi, Eiji; Matsumura, Takehiko; US2011/160206; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider