Day: November 17, 2020

23088-23-5, Methyl 6-Quinoxalinecarboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 2-(2-Chloro-4-methoxy-phenyl)-1-quinoxalin-6-yl-ethanone A 2M solution of tert-butylmagnesium chloride (CAS Reg. No. 677-22-5) in diethyl ether (5.9 ml) was added to 2-chloro-4-methoxyphenylacetic acid (1.173 g, CAS Reg. No. 91367-09-8) in THF (10 ml). The mixture was stirred at room temperature for 30 min. A solution of methyl 6-quinoxalinecarboxylate (1 g, CAS Reg. No. 23088-23-5) in THF (3 ml) was added and the resulting mixture was stirred overnight. Aqueous HCl (25%, 1.5 ml) and water (30 ml) were added and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and then concentrated to an oil. The residue was purified by flash chromatography (SiO2, EtOAc/heptane 1:2) to give the title compound (480 mg) as a light brown solid. MS (m/e)=313.2 [M+H+].

23088-23-5, The synthetic route of 23088-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249139; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in acetic acid (50 mL), o-phenylenediamine (1.62 g,0.015 mol) was added and the reaction mixture was refluxed for 7 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried, crystallized fromethanol and purified by column chromatography using an elution system chloroform : methanol (10 :0.3, v/v) to give the product. Yield: 77%; (yellow powder): m.p. over 300C; IR (KBr, cm -1 ): 3182, 3112 (2NH), 1605 (C=N).1 H NMR (DMSO-d 6 , delta , ppm): 7.30-7.96 (m, 7H, Ar-H), 11.63, 11.70 (2s, br, 2H, 2NH; exchangeablewith D 2 O). 13 C NMR (DMSO-d 6 , delta , ppm): 114.43-143.23 (12Ar-C), 144.88, 145.03 (2C=N). MS(m/z), 312 (M + ; 100%), 313 (M + + 1; 23%), 314 (M ++ 2; 99.9%). Analysis: calcd. for C 14 H 9 BrN 4(313.15): C, 53.70; H, 2.90; N, 17.89%; found: C,53.92; H, 2.79; N, 18.04%., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

59564-59-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59564-59-9,3,4-Dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

A solution of 3,4-dihydroquinoxalin-2-(1H)-one (2.9 g, 19.6 mmol) in methanol (20 mL) Sodium cyanoborohydride (2.5 g, 39.7 mmol) was added, Paraformaldehyde (0.9 g) and glacial acetic acid (1 mL) The reaction was stirred at 25 C for 4 hours, Sodium cyanoborohydride (1.2 g, 19.0 mmol) was added, Paraformaldehyde (0.45 g) and hydrochloric acid (0.5 mL), The reaction was heated to 50 C for 5 hours. The reaction solution was cooled to room temperature, The pH was adjusted to 8 with saturated aqueous sodium bicarbonate solution, Ethyl acetate (50 mL x 3) was added, Combine organic phase, Dried over anhydrous sodium sulfate, filter, concentrate, To give the title compound (3.0 g, yield 94.5%).

The synthetic route of 59564-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Xuanzhu Pharmaceutical Co., Ltd.; Wu, Yongqian; (31 pag.)CN106317027; (2017); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

74003-63-7,74003-63-7, 3-Methylquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) 0.38 g of MQCA, 0.20 g of aminobutyric acid and a small amount of DMAP were added to 20 mL of dry DMF;(2) Under the condition of 0 C, 0.8 g of DCC was slowly added dropwise to the mixture of 5 mL of dry DMF. After the dropwise addition, the temperature was gradually raised to room temperature and the reaction was continued for 40 h.(3) the solvent is distilled off and purified by column chromatography to obtain the condensate of MQCA and aminobutyric acid, which is the product of formula (1).

74003-63-7 3-Methylquinoxaline-2-carboxylic acid 6484678, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Kwinbon Biotechnology Co., Ltd; He, Fangyang; Wan, Yuping; Sun, Zhen; Feng, Jing; Luo, Xiaoqin; Cui, Haifeng; Yu, Houmei; Han, Jingpeng; Duan, Yingying; (12 pag.)CN103304495; (2016); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 11b (103.8 mg, 451 mumol), 6-bromoquinoxaline (142 mg, 679 mumol), Bu4NOAc (271 mg, 0.9 mmol) and Pd(OAc)2 (15.2 mg, 67.5 mol) in NMP (0.9 mL). The reaction mixture was stirred for 22 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure, diluted with water, and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12b (91 mg, 56%) as a pale yellow solid. TLC: Rf 0.37 (1:1 hexane/EtOAc). mp: 96.0-98.0 oC. 1H-NMR (400 MHz, CDCl3) delta 8.90 (AB quartet, 2H, J = 2.0 Hz), 8.09 (d, 1H, J = 8.8 Hz), 8.07 (d, 1H, J = 2.0 Hz) 7.72 (t, 1H, J = 8.0 Hz), 7.63 (dd, 1H, J = 8.8 Hz, J = 2.0 Hz), 7.60 (d, 1H, J = 8.0 Hz), 7.12(d, 1H, J = 8.0 Hz), 2.80 (m, 2H), 2.20 (s, 3H), 1.69-1.60 (m, 3H), 0.86 (d, 6H, J = 6.4 Hz). 13C-NMR (100 MHz, CDCl3) delta 158.2, 149.3, 147.8, 145.9, 145.8, 142.8, 142.7, 139.1, 132.6, 132.2, 131.0, 130.4, 129.2, 123.5, 115.2, 38.7, 27.8, 23.8, 23.1, 22.5. HRMS (ESI) calcd. for C21H23N6 (M+H): 359.1979; found 359.1983., 50998-17-9

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

50998-17-9,50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13A 1-Quinoxalin-6-yl-ethanone A solution of 6-bromo-quinoxaline (261 mg, 1.25 mmol), 1-ethoxyvinyltri-n-butyltin (0.47 mL, 1.4 mmol), palladium(II) acetate (16 mg) and tri-t-butylphosphonium tetrafluoroborate (41 mg) in anhydrous DMF (4 mL) under a nitrogen atmosphere was heated at 120 C. for 1 hr. The reaction mixture was cooled to ambient temperature and partitioned between ethyl acetate (25 mL) and H2O (10 mL). The organic extraction was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was chromatographed on silica gel eluding with ethyl acetate:hexanes (1:1) to provide 110 mg of the title compound. 1H NMR (300 MHz, CDCl3) delta 2.79 (s, 3H), 8.18 (d, J=9 Hz, 1H), 8.36 (dd, J=9 Hz, J=3 Hz, 1H), 8.70 (d, J=3 Hz, 1H), 8.95 (s, 2H); MS (DCl/NH3) m/z 173 (M+H)+.

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/272736; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0,49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1B) Method B: A suspension of ethyl 3-chloroquinoxaline-2-carboxylate (11.5 g, 48.6 mmol), trimethylboroxine (6.06 g, 48.6 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (1.98 g, 2.42 mmol), and potassium carbonate (13.4 g, 97.0 mmol) in 1,4-dioxane (162 mL) was heated for 4.5 hour at 115 C. After being cooled to ambient temperature, the reaction mixture was filtrated through celite with ethyl acetate (500 mL). The filtrate was combined and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1 to 2:1) followed by recrystallization from ethanol-water (1/4) to give ethyl 3-methylquinoxaline-2-carboxylate as colorless crystals (8.36 g, 80%). mp 74-75 C. MS (APCI): m/z 217 (M+H).

The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kawanishi, Eiji; Matsumura, Takehiko; US2011/160206; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

80636-30-2, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8; (7J?)-2-r(3,3-Dimethyl-2-oxo-3,4-dihydroquinoxalin-lf2H)-yl)methyl1-3′-methyl-6.8-dihvdro- 2’H,5’H-spiro[cvclopenta(g1quinoline-7,4′-imidazolidine1-2′,5′-dione; To a solution of 3,3-dimethy~3,4-dihydroquinoxalm-2(lH)-one (56 mg, 0.32 mmol) in DMF (1 mL) at ambient temperature was added sodium hydride (13 mg, 0.32 mmol, 60% dispersion in mineral oil). The resulting mixture was stirred for 20 min, then (i?)-2- (chloromethy^-S’-methyl-jS-dihydro-Z’HjS’H-spirotcyclopentafgJquinoline-T^’-imidazolidine]- 2.,5′-dione (20 mg, 0.063 mmol, described in Intermediate 18) was added and the resulting mixture was stirred at ambient temperature for 1 h. The reaction mixture was purified directly by HPLC using a reversed phase Cl 8 column and eluting with a gradient of H2theta:CH3CN:CF3Ctheta2H – 90:10:0.1 to 5:95:0.1. The pure, product-containing fractions were combined and concentrated to give the title compound as the trifluoroacetate salt. MS: m/z = 456 (M + 1). HRMS: m/z = 456.2033; calculated m/z = 456.2030 for C26H26N5O3., 80636-30-2

The synthetic route of 80636-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; STUMP, Craig, A.; QUIGLEY, Amy, G.; THEBERGE, Cory, R.; WOOD, Michael, R.; WO2010/107605; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1233318-23-4,Methyl 2-(quinoxalin-6-yl)acetate,as a common compound, the synthetic route is as follows.

To dimethyl carbonate (30 mL) cooled at 0 was added potassium tert-butanolate (3.8 g, 34.12 mmol) in portions. The resultant mixture was stirred at 0 for 1 hour. Methyl 2- (quinoxalin-6-yl) acetate (2.3 g, 11.37 mmol) was added. The resultant mixture was slowly warmed up to room temperature and stirred for 1 hour. The reaction mixture was heated to 90 and stirred for 1.5 hours. After cooling to room temperature, the mixture was diluted with EtOAc (150 mL) , washed with saturated NH4Cl (80 mL) and brine (50 mL) , dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by flash column (petroleum ether/ethyl acetate3: 1) to obtain dimethyl 2- (quinoxalin-6-yl) malonate (2.0 g) as a yellow solid. 1H NMR (CHLOROFORM-d) : delta 8.89 (s, 2H) , 8.10 -8.19 (m, 2H) , 7.91 (dd, J 8.7, 2.0 Hz, 1H) , 4.95 (s, 1H) , 3.82 (s, 6H) . LC-MS: m/z 261.1 (M+H) +., 1233318-23-4

As the paragraph descriping shows that 1233318-23-4 is playing an increasingly important role.

Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6298-37-9, To a solution of 35C enantiomer 1 (0.0251 g, 0.078 mmol) in THF (1.205 ml) was added 4-nitrophenyl carbonochloridate (0.017 g, 0.082 mmol). The reaction was stirred at rt for 30 min. To this reaction were added quinoxalin-6-amine (0.034 g, 0.235 mmol) and triethylamine (0.033 ml, 0.235 mmol). The reaction was heated at 50 C overnight, then allowed to cool to RT. The reaction was diluted with H20 and EtOAc. The layers were separated and the aqueous phase was extracted with EtOAc (3X). The organic phases were combined, dried over Na2S04, filtered and concentrated to give 35D as a brown residue. The crude material was used without further purification.

6298-37-9 Quinoxalin-6-amine 0, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; CHEN, Bin; CHEN, Libing; SHAN, Weifang; WO2014/150646; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider