80636-30-2, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 8; (7J?)-2-r(3,3-Dimethyl-2-oxo-3,4-dihydroquinoxalin-lf2H)-yl)methyl1-3′-methyl-6.8-dihvdro- 2’H,5’H-spiro[cvclopenta(g1quinoline-7,4′-imidazolidine1-2′,5′-dione; To a solution of 3,3-dimethy~3,4-dihydroquinoxalm-2(lH)-one (56 mg, 0.32 mmol) in DMF (1 mL) at ambient temperature was added sodium hydride (13 mg, 0.32 mmol, 60% dispersion in mineral oil). The resulting mixture was stirred for 20 min, then (i?)-2- (chloromethy^-S’-methyl-jS-dihydro-Z’HjS’H-spirotcyclopentafgJquinoline-T^’-imidazolidine]- 2.,5′-dione (20 mg, 0.063 mmol, described in Intermediate 18) was added and the resulting mixture was stirred at ambient temperature for 1 h. The reaction mixture was purified directly by HPLC using a reversed phase Cl 8 column and eluting with a gradient of H2theta:CH3CN:CF3Ctheta2H – 90:10:0.1 to 5:95:0.1. The pure, product-containing fractions were combined and concentrated to give the title compound as the trifluoroacetate salt. MS: m/z = 456 (M + 1). HRMS: m/z = 456.2033; calculated m/z = 456.2030 for C26H26N5O3., 80636-30-2
The synthetic route of 80636-30-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP &; DOHME CORP.; STUMP, Craig, A.; QUIGLEY, Amy, G.; THEBERGE, Cory, R.; WOOD, Michael, R.; WO2010/107605; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider