With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.,50998-17-9
To a solution of 11g (30 mg, 113 mumol), 6-bromoquinoxaline (36 mg, 172 mol), Bu4NOAc (66.2 mg, 220 mol) and Pd(OAc)2 (3.7 mg, 16.5 mol) in NMP (0.5 mL ). The reaction mixture was stirred for 32 h at 100 oC and cooled to room temperature. The mixture was concentrated under reduced pressure. Diluted with water and extracted with EtOAc (3 ¡Á 5 mL). The EtOAc solution was washed with brine (5 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (1:1 hexane/EtOAc) to afford the compound 12g (6.1 mg, 14%) as a pale yellow solid. TLC: Rf 0.3 (1:1 hexane/EtOAc). mp: 133136 oC. 1H-NMR (400 MHz, CDCl3) delta 8.83 (d, 1H, J = 2.0 Hz), 8.80 (d, 1H, J = 2.0 Hz), 7.99 (d, 1H, J = 8.8 Hz), 7.92 (d, 1H, J = 2.0 Hz), 7.75 (t, 1H, J = 8.0 Hz), 7.65-7.62 (m, 3H), 7.33 (m, 1H), 7.17 (d, 1H, J = 8.0 Hz), 7.03 (td, 1H, J = 8.0 Hz, J = 1.2 Hz), 6.78 (d, 1H, J = 8.0 Hz), 3.27 (s, 3H), 2.27 (s, 3H). 13C-NMR (100 MHz, CDCl3) delta 158.5, 156.7, 149.4, 145.6, 145.5, 144.2, 142.7, 142.6, 139.2, 134.1, 132.1, 131.9, 131.8, 130.5, 130.1, 128.6, 123.9, 121.1, 119,6, 116.1, 111.2, 54.8, 23.9. HRMS (ESI) calcd. for C23H19N6O (M+H): 395.1615; found 395.1620.
The synthetic route of 50998-17-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Fei; Park, Yunjeong; Hah, Jung-Mi; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1083 – 1086;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider