887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
7.1: tert-Butyl ester of 4-(5-bromo-pyridin-2-yl)-3,4-dihydro-2H-quinoxaline-1-carboxylic acid16 g of tert-butyl ester of 3,4-dihydro-2H-quinoxaline-1-carboxylic acid is put in a 1-liter three-necked flask, under nitrogen atmosphere. 325 ml of pyrrolidinone and 14.70 ml of 5-bromo-2-fluoropyridine are added. It is cooled in an ice bath. 15.93 g of potassium tert-butylate is added a little at a time. The reaction mixture is stirred cold for 1 h, then the reaction mixture is allows to return to room temperature. It is stirred for 1 h. It is cooled in an ice bath and is hydrolyzed slowly. The organic phase is extracted with ethyl ether. The combined organic phases are washed with water, then with saturated NaCl solution. The reaction mixture is dried, with stirring, over Na2SO4, then filtered on a frit and concentrated under reduced pressure. 10.1 g of tert-butyl ester of 4-(5-bromo-pyridin-2-yl)-3,4-dihydro-2H-quinoxaline-1-carboxylic acid is obtained in the form of a white solid, after purification on a silica column (heptane/EtOAc gradient: 5 to 20% of EtOAc).M+H+=392, 887590-25-2
As the paragraph descriping shows that 887590-25-2 is playing an increasingly important role.
Reference£º
Patent; SANOFI; US2012/165337; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider