With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98416-72-9,6-Bromo-2-chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.,98416-72-9
4.11 6-Bromo-3-methyl-2-(phenylthio)quinoxaline (11) To a solution of thiophenol (0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) was added and refluxed for 1 h, then (5, 0.01 mol) was added and the mixture was further refluxed for 12 h (monitored by TLC). After completion of the reaction, the mixture was filtered and the excess of acetonitrile was evaporated under reduced pressure, dried, crystallized from petroleum ether and purified by a silica gel column chromatography (chloroform) to produce crude product. Yield: 78%; (brown powder): mp 59-61 C; IR (KBr) numax in cm-1: 2956, 2851 (aliphatic C-H), 1597 (C=N); 1H NMR (DMSO-d6, 500 MHz): delta 2.65 (s, 3H, CH3), 7.40-7.80 (m, 8H, Ar-H); 13C NMR (DMSO-d6, 125 MHz): delta 20.55 (CH3), 114.23-133.21 (12Ar-C), 154.60, 154.64 (2C=N); MS (m/z), 109 (M+-C9H7N2; 100%), 330 (M+; 3%), 331 (M++1; 6%), 332 (M++2; 3%). Anal. Calcd for C15H11BrN2S (331.23): C, 54.39; H, 3.35; N, 8.46. Found: C, 54.39; H, 3.35; N, 8.46.
98416-72-9 6-Bromo-2-chloro-3-methylquinoxaline 13487186, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R.; Eissa, Sally I.; Ammar, Yousry A.; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6560 – 6572;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider