Day: November 19, 2020

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in DMF (50 mL), 4-(trifluoromethyl)aniline (1.61 g, 0.01 mol) was added. The reaction mixture was refluxed for 24 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the solid residue that formed was filtered, washed with water, dried and crystallized from petroleum ether (80-100C) to give 4. Yield: 40%; (brown powder): m.p. 157-159 O C;IR (KBr, cm -1 ): 3158 (NH), 1603 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.25-7.82 (m, 7H, Ar-H), 9.71(s, br, 1H, NH; exchangeable with D 2 O). 13 C NMR(DMSO-d 6 , delta , ppm): 121.15-147.09 (12Ar-C, CF 3 ),152.69, 152.86 (2C=N). MS (m/z), 336 (M + -C 2 H 3 F 2 ; 100%), 401 (M + ; 88%), 402 (M + + 1; 60%),403 (M + + 2; 57%), 404 (M + + 3; 62%), 405 (M + + 4;52%). Analysis: calcd. for C 15 H 8 BrClF 3 N 3 (402.60):C, 44.75; H, 2.00; N, 10.44%; found: C, 44.61; H,2.26; N, 10.69%.

108229-82-9, 108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.

91-19-0, Quinoxaline (0.65g, 5 mmol), pyruvic acid (1.32g, 15 mmol), AgNO3 (0.068g, 0.4 mmol), (NH4) 2S2O8 (1.71g, 7.5 mmol), CF3CO2H (1.7g, 15 mmol) were dissolved in a 1 : 1 mixture of DCM/H2O (50ml). The reaction mixture was stirred at 40 C. After cooling to room temperature the mixture was extracted with DCM, washed with brine and dried over Mg S04, then evaporated to give 1-quinoxalin-2-yl-ethanone (0. 89g, 100%).

91-19-0 Quinoxaline 7045, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; F2G LTD; WO2005/92304; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59564-59-9,3,4-Dihydroquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

59564-59-9, EXAMPLE 294 4-Methoxycarbonyl-1,2,3,4-tetrahydroquinoxalin-2-one (IV) To 2.99 g of 1,2,3,4-tetrahydroquinoxalin-2-one (IV) in 30 ml of methyl tert-butyl ether are added 2.18 ml of methyl chloroformate. After stirring for 1 hr, 4.9 ml of diisopropylethylamine are added. The reaction is stirred an additional 30 min and then concentrated under reduced pressure. The residue is partitioned between dichloromethane and aq. sodium bicarbonate and the organic layers dried over sodium sulfate and concentrated. The crude product is crystallized from dichloromethane/hexane/ethyl ether to give the title compound, NMR (CDCl3) 3.84, 4.45, 6.87, 7.11, 7.65, 8.27 delta.

As the paragraph descriping shows that 59564-59-9 is playing an increasingly important role.

Reference£º
Patent; The Upjohn Company; US5541324; (1996); A;,
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80636-30-2, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,80636-30-2

EXAMPLE 296 3,3-Dimethyl-4-[(1-methyl)ethyl]oxycarbonyl-1,2,3,4-tetrahydroquinoxalin-2-one (IV) To 2.28 g of 4-chlorocarbonyl-3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one (prepared by the method of Example 32 but using 3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one rather than 6-fluoro-3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one) in 25 ml of 2-propanol (the starting material is not all in solution) are added 0.694 g of lithium isopropoxide. After about 1.5 hr the reaction mixture became homogeneous and then again heterogeneous as the product precipitated out. After a total of 2 hr the solvent is removed under reduced pressure and the residue is partitioned between dichloromethane aid saline. The organic layers are dried over sodium sulfate and the filtrate is concentrated. Ether is added and the resulting solid is collected to give the title compound. NMR (CDCl3) 1.28, 1.63, 5.01, 6.80, 6.98-7.11, 7.27, 7.96 delta.

80636-30-2 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one 595203, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; The Upjohn Company; US5541324; (1996); A;,
Quinoxaline – Wikipedia
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55687-02-0, 6-Bromo-2-chloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-bromo, 2-chloroquinoxaline (0.700 g, 2.8 mmol) and Triethylamine (0.87 g, 8.6 mmol) were dissolved in DMSO (15 mL) at room temperature and (f?)-1-(3-Fluoro-phenyl)- ethylamine hydrochloride (0.400 g, 2.8 mmol) was added. The reaction mixture was stirred at RT for 16 hours. After completion of reaction (confirmed by TLC), water (10OmL) was added to the reaction mixture and it was extracted with ethyl acetate (50 mL x 3). The organic layer was washed with water (15 mL), brine (15 mL), and was then dried over Na2SO4. The organic layer was concentrated in vacuo to afford the crude product.The crude product was adsorbed on silica gel and was purified by column chromatography using neutral silica gel of 60-120 mesh size. Methanol (1-1.5 %) was used as a gradient in DCM for elution of the title compound as a solid (0.35 g, 36%)., 55687-02-0

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

The title compound was prepared from 6-Bromo-2-chloro-quinoxaline (3 g, 12.32 mmol) using the method applied for example 5 with the following exceptions: (1 ) in step 1 , 1-Methyl-1-phenyl-ethylamine (1.99 g, 14.72 mmol) was used instead of (R)-1 -(3-Fluoro-phenyl)-ethylamine and Nu,Nu-Diisopropylethylamine (8.4 mL, 6.23 g, 48.23 mmol) was used instead of trimethylamine (2) Title product was isolated as the free base. Yield of final step: 0.04 g (41 %)., 55687-02-0

The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; WALKER, David Winter; (166 pag.)WO2016/170163; (2016); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13708-12-8,5-Methylquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 5-methylquinoxaline (9.50 g, 65.97 mmol) in CH3CN (80 mL) was added 1-bromopyrrolidine-2,5-dione (27.00 g, 151.74 mmol) at room temperature. The resulting solution was stirred for 16 h at 60 C. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate (500 mL). The insoluble solids in the mixture were filtered out and the filtrate was washed with brine and dried over Na2504. The solvent was removed under reduced pressure to yield 5-bromo-8-methylquinoxaline as brown solid (6.00 g, 4 1%). MS: m/z = 222.9 [M+Hj .

13708-12-8, 13708-12-8 5-Methylquinoxaline 61670, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; SHERER, Brian A.; CHEN, Xiaoling; CLEARY, Esther; BRUGGER, Nadia; (198 pag.)WO2018/31434; (2018); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13311-79-0,6-Methoxy-1,2,3,4-tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.

General procedure: Dichloroacetyl chloride (2.4 mL, 24 mmol) was added dropwise to a suspension of 2 (10 mmol) and Na2CO3 (2.55g, 24 mmol) in benzene (30 ml) at room temp with stirring. The mixture was stirred continuously for 1 hr and then it was taken up in a mixture of water and EtOAc. The organic phase was washed with saturated NaCl aq, dried over anhyNa2SO4 and vacuum distillation gave the residue. Recrystallization of the residue with ethanol gave pure products 4a-f., 13311-79-0

13311-79-0 6-Methoxy-1,2,3,4-tetrahydroquinoxaline 12549514, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Ye, Fei; Liu, Xin-Ying; Qu, Li-Hua; Fu, Ying; Zhao, Li-Xia; Qu, Hai-Hao; Indian Journal of Heterocyclic Chemistry; vol. 24; 2; (2014); p. 167 – 174;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

76982-23-5, 5-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76982-23-5, A mixture of 5-bromoquinoxaline (300 mg, 1.43 mmol, 1 eq), potassium [2- (benzyloxy)ethyl]-trifluoroboranuide (695 mg, 2.87 mmol, 2 eq), Pd(OAc)2 (65 mg, 0.29 mmol, 0.2 eq), Butyldi-l-adamantylphosphine (103 mg, 0.29 mmol, 0.2 eq) and Cs2C03 (1169 mg, 3.59 mmol, 2.5 eq) in Toluene (4 mL) and H20 (1 mL) was stirred overnight at 100 C. The reaction was quenched with water and extracted with EtOAc. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with petroleum ether/EtOAc to afford 5-[2-(benzyloxy)ethyl]quinoxaline (321 mg, 85%) as a yellow oil. LCMS: m/z = 265.1 [M+H]+.

The synthetic route of 76982-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIPELINE THERAPEUTICS, INC.; XIONG, Yifeng; SCHRADER, Thomas; CHEN, Austin; ROPPE, Jeffrey Roger; BACCEI, Jill Melissa; BRAVO, Yalda; (199 pag.)WO2019/241131; (2019); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76982-23-5,5-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

76982-23-5, (1) In a 250mL three-neck bottle,Pass in nitrogen,Add 0.02mol of raw materials I-8 and dissolve in 100ml of tetrahydrofuran (THF).0.024mol bis (pinacolate) diboron,0.0002mol (1,1′-bis (diphenylphosphine) ferrocene) dichloropalladium (II) and 0.04mol potassium acetate were added, the mixture was stirred, and the mixed solution of the above reactants was heated to reflux at a reaction temperature of 80 C 5 hours; after the reaction is completed, cool and add 100 ml of water, and filter the mixture, take the filter cake and dry in a vacuum oven. The obtained residue was separated and purified through a silica gel column to obtain intermediate E3; the purity by HPLC was 99.1%, and the yield was 86.3%

76982-23-5 5-Bromoquinoxaline 610437, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Li Chong; Cai Xiao; Tang Dandan; Zhang Zhaochao; (70 pag.)CN110878092; (2020); A;,
Quinoxaline – Wikipedia
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