With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13708-12-8,5-Methylquinoxaline,as a common compound, the synthetic route is as follows.
To a solution of 5-methylquinoxaline (9.50 g, 65.97 mmol) in CH3CN (80 mL) was added 1-bromopyrrolidine-2,5-dione (27.00 g, 151.74 mmol) at room temperature. The resulting solution was stirred for 16 h at 60 C. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate (500 mL). The insoluble solids in the mixture were filtered out and the filtrate was washed with brine and dried over Na2504. The solvent was removed under reduced pressure to yield 5-bromo-8-methylquinoxaline as brown solid (6.00 g, 4 1%). MS: m/z = 222.9 [M+Hj .
13708-12-8, 13708-12-8 5-Methylquinoxaline 61670, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK PATENT GMBH; SHERER, Brian A.; CHEN, Xiaoling; CLEARY, Esther; BRUGGER, Nadia; (198 pag.)WO2018/31434; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider