With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76982-23-5,5-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
76982-23-5, (1) In a 250mL three-neck bottle,Pass in nitrogen,Add 0.02mol of raw materials I-8 and dissolve in 100ml of tetrahydrofuran (THF).0.024mol bis (pinacolate) diboron,0.0002mol (1,1′-bis (diphenylphosphine) ferrocene) dichloropalladium (II) and 0.04mol potassium acetate were added, the mixture was stirred, and the mixed solution of the above reactants was heated to reflux at a reaction temperature of 80 C 5 hours; after the reaction is completed, cool and add 100 ml of water, and filter the mixture, take the filter cake and dry in a vacuum oven. The obtained residue was separated and purified through a silica gel column to obtain intermediate E3; the purity by HPLC was 99.1%, and the yield was 86.3%
76982-23-5 5-Bromoquinoxaline 610437, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Li Chong; Cai Xiao; Tang Dandan; Zhang Zhaochao; (70 pag.)CN110878092; (2020); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider