With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.
To a solution of 2-chloro-3-methylquinoxaline L [45] (1.0 g, 5.6mmol) and 2,4-dichloroaniline (0.91 g, 5.6mmol) in anhydrous DMF (10mL), Cs2CO3 (1.82 g, 5.6mmol) was added under inert atmosphere. The mixture was stirred at 70C for 24h. After cooling, water then CH2Cl2 were added. The organic layer was then washed five times with water and dried with Na2SO4. After filtration and evaporation, the resulting solid was purified by silica gel column chromatography (eluent: Petroleum Ether/CH2Cl2 7/3 then 1/1) to afford N-(2,4-dichlorophenyl)-3-methylquinoxalin-2-amine. Yield 19%. White powder. mp 152C. 1H NMR (250MHz, CDCl3) delta=9.06 (d, J=9.0 Hz, 1H), 7.90 (d, J=8.2 Hz, 1H), 7.83 (d, J=8.2 Hz, 1H), 7.67-7.57 (m, 1H), 7.57-7.30 (m, 4H), 2.78 (s, 3H). 13C NMR (63MHz, CDCl3) delta=147.5, 145.2, 140.4, 138.0, 135.3, 129.6, 128.8, 128.4, 128.0, 127.6, 127.0, 126.4, 123.2, 121.4, 21.1. LC-MS (ESI, 35 eV): tR=5.49min, m/z 304 [M+H]+., 32601-86-8
As the paragraph descriping shows that 32601-86-8 is playing an increasingly important role.
Reference£º
Article; Desroches, Justine; Kieffer, Charline; Primas, Nicolas; Hutter, Sebastien; Gellis, Armand; El-Kashef, Hussein; Rathelot, Pascal; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 68 – 86;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider