With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.
6924-66-9, PyBOP (164 mg, 315 muiotaetaomicronIota) was added to a mixture of 8-amino-2-(2-chloro-4,6-difluorophenyl)- 2-azaspiro[4.5]decan-1 -one (isomer 1 , intermediate I56) (150 mg, 55 % purity, 262 muiotaetaomicronIota), quinoxaline-5-carboxylic acid (57.1 mg, 328 muiotaetaomicronIota) and N,N-diisopropylethylamine (230 muIota, 1 .3 mmol) in DMF (2.9 ml) and the mixture was stirred over night at room temperature. For workup, the reaction mixture was concentrated and the residue was purified by preparative HPLC to give the title compound 61 .3 mg (49 % yield). LC-MS (Method 1): Rt= 1.17 min; MS (ESIpos): m/z = 471 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1.485 (0.75), 1.498 (0.85), 1.515 (2.19), 1.527 (2.38), 1.546 (2.66), 1.557 (2.60), 1.576 (1.35), 1.588 (1.22), 1.700 (5.70), 1.709 (5.70), 2.028 (2.94), 2.036 (3.07), 2.060 (2.85), 2.067 (2.63), 2.187 (3.41), 2.204 (6.95), 2.221 (4.07), 2.327 (1.88), 2.523 (4.79), 2.665 (1.41), 2.669 (1.91), 2.673 (1.41), 3.511 (1.03), 3.530 (2.32), 3.535 (2.00), 3.552 (2.88), 3.570 (1.41), 3.621 (1.47), 3.637 (2.60), 3.655 (1.91), 3.661 (2.16), 3.679 (0.97), 3.896 (1.16), 3.906 (1.44), 3.916 (1.19), 3.925 (1.41), 3.935 (1.13), 7.507 (1.47), 7.514 (2.07), 7.530 (2.22), 7.538 (4.04), 7.545 (3.19), 7.549 (3.01), 7.556 (2.54), 7.561 (3.13), 7.567 (3.23), 7.578 (1.78), 7.961 (3.57), 7.981 (5.01), 8.000 (4.26), 8.255 (4.76), 8.258 (4.85), 8.275 (4.23), 8.279 (4.07), 8.428 (4.60), 8.431 (4.54), 8.446 (4.32), 8.449 (3.98), 9.078 (16.00), 9.079 (15.72), 9.763 (3.66), 9.782 (3.60)
6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider