Day: November 23, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.148231-12-3,5,8-Dibromoquinoxaline,as a common compound, the synthetic route is as follows.

In N2in the gas purification system, the carbazole is dissolved in 1,4-dioxane solvent, and by adding CuI and K3PO4. Add another 5,8- […][…] (1.1 equivalent) and trans -1,2-diamino cyclohexane. In the solution 110 C and the temperature of the refluxing under stirring 24 hours. After the completion of reaction, to the room temperature and cooling the solution and distilled water extraction by ethyl acetate. From the extraction of using magnesium sulphate remove the moisture in the organic layer, and removing the remaining organic solvent. The material through the use of hexane and ethyl acetate to carry out wet refining column chromatography, thereby obtaining compound “l”. (Yield: 48%)

148231-12-3, The synthetic route of 148231-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Display Co., Ltd.; Yang, Joonghwan; Yoon, Kyungjin; Noh, Hyojin; Yoon, Daewi; Shin, Inae; Kim, Junyun; (63 pag.)CN105585577; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.

To a solution of 2-chloro-3-methylquinoxaline L [45] (650mg, 3.6mmol) and 4-chlorophenol (0.37mL, 3.6mmol) in anhydrous DMF (15mL), Cs2CO3 (1.19 g, 3.6mmol) was added under inert atmosphere. The mixture was stirred at 70C overnight. After completion of the reaction, water was added, leading to a precipitate which was separated by filtration. The resulting precipitate was then thoroughly washed with water. The precipitate was dissolved in CH2Cl2 and dried with Na2SO4. After filtration and evaporation, the resulting solid was purified by silica gel column chromatography (eluent: Petroleum Ether/CH2Cl2 1/1) to afford 2-(4-chlorophenoxy)-3-methylquinoxaline. Yield 85%. Off-white powder. mp 108C. 1H NMR (250MHz, CDCl3) delta=7.69 (dd, J=6.1, 3.7 Hz, 1H), 7.57 (dd, J=6.3, 3.5 Hz, 2H), 7.46-7.38 (m, 2H), 7.28-7.19 (m, 2H), 2.81 (s, 3H). 13C NMR (63MHz, CDCl3) delta=155.8, 151.5, 147.9, 139.6, 139.4, 130.6, 129.7, 129.4, 128.1, 127.6, 127.4, 123.3, 20.7. LC-MS (ESI, 35 eV): tR=4.35min, m/z 271 [M+H]+., 32601-86-8

32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Desroches, Justine; Kieffer, Charline; Primas, Nicolas; Hutter, Sebastien; Gellis, Armand; El-Kashef, Hussein; Rathelot, Pascal; Verhaeghe, Pierre; Azas, Nadine; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 68 – 86;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.

879-65-2, j. Quinoxaline-2-carboxylic Acid {(S)-3-methyl-1-[3-hydroxy-1-(1-oxy-pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}amide To a solution of the compound of Example 1i (320 mg, 0.73 mmol) in CH2Cl2 was added triethylamine (0.15 mL, 1.09 mmol), EDC (140 mg, 0.73 mmol), HOBt (99 mg, 0.73 mmol) and quinoxaline-2-carboxylic acid (127 mg, 0.73 mmol). The reaction was stirred until complete by TLC analysis. Workup and column chromatography of the residue gave the title compound: MS(EI) 556 (M+).

As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.

Reference£º
Patent; SmithKline Beecham Corporation; US6583137; (2003); B1;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2).

49679-45-0, 49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.

6924-66-9, To a solution of 8-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 2 Intermediate 113), (75.0 mg, 253 mupiiotaomicronIota) in DMF (2.6 ml) was added PyBOP (145 mg, 278 muiotaetaomicronIota), N,N-diisopropylethylamine (180 muIota, 1.0 mmol) and quinoxaline-5-carboxylic acid (44.0 mg, 253 muiotaetaomicronIota) and the reaction was stirred for 16 h at room temperature. For work-up, brine (45 ml) was added and the resulting precipitate was filtrated. The residue was dissolved in DMSO and the crude product was purified by HPLC (Method 6) to give after trituration with water the title product (54 mg)LC-MS (Method 4): Rt = 1 .15 min; MS (ESIpos): m/z = 453 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .548 (5.49), 1 .581 (5.92), 1 .788 (2.48), 1 .820 (5.92), 1 .848 (5.61 ), 1 .901 (6.65), 1 .992 (4.72), 2.001 (4.87), 2.026 (6.99), 2.052 (3.52), 2.124 (6.90), 2.142 (12.41 ), 2.158 (6.99), 2.327 (1 .99), 2.539 (3.37), 2.668 (1 .96), 3.628 (7.72), 3.645 (13.55), 3.662 (7.1 1 ), 4.224 (3.62), 7.293 (2.54), 7.299 (2.85), 7.314 (5.06), 7.321 (5.27), 7.335 (3.13), 7.343 (3.03), 7.485 (5.24), 7.499 (5.85), 7.507 (5.06), 7.521 (4.14), 7.579 (5.33), 7.586 (5.36), 7.600 (5.39), 7.607 (5.00), 7.975 (4.54), 7.995 (7.88), 8.014 (5.33), 8.270 (7.1 1 ), 8.274 (7.05), 8.291 (6.50), 8.295 (6.50), 8.300 (3.92), 8.522 (7.02), 8.526 (6.80), 8.541 (6.59), 9.079 (16.00), 9.087 (15.66), 10.452 (3.80), 10.471 (3.65)

The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
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6344-72-5, 6-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6344-72-5, Example 3 Preparation of a Solid Sample of 6-bromomethyl-quinoxaline In a 100 ml flask, 6-methyl-quinoxaline (2.5 g, 17.4 mmol) was dissolved together with N-bromosuccinimide (4.63 g, 19 mmol) and benzoyl peroxide (0.3 g, 1.24 mmol) in 70 g of 1,2-dichloroethane. The solution was refluxed for 150 minutes and analyzed. The concentrations of the reactants and some of their molar ratios are shown below: The solution was cooled in the freezer overnight and the solid residue was separated by filtration. The solid was washed with pentane and the washings were combined with the liquid fraction. The clear reddish solution was then vacuum dried to give an orange solid that was used in the preparation of 6-hydroxymethyl-quinoxaline.

As the paragraph descriping shows that 6344-72-5 is playing an increasingly important role.

Reference£º
Patent; Air Products and Chemicals, Inc.; US6548670; (2003); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83570-42-7,1-(Quinoxalin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

Titanium tetraisopropoxide (0.08 mL, 0.27 mmol) was added to a stirred suspension of Intermediate 3b (57 mg, 0.25 mmol) and l-(quinoxalin-6-yl)ethanone (CAS: 83570-42- 7; 50 mg, 0.29 mmol) in THF (1.5 mL) at rt and under N2 atmosphere. The mixture was stirred into a sealed tube at 80 C for 16 h. Then sodium cyanoborohydride (28 mg, 0.45 mmol) was added and the mixture was further stirred at 80 C for 16 h. Then, NaHC03 (aq. sat. soltn.) and DCM were added to the mixture. The solvent was evaporated in vacuo and the crude product was purified by flash column (0323) chromatography (silica gel, 7N solution of NH3 in MeOH in DCM, from 0/100 to 10/90) and then by RP HPLC (Stationary phase: C18 XBridge 30 x 100 mm 5 muetaiota; mobile phase: gradient from 81 % 1 OmM NH4CO3H pH 9 solution in water, 19% (0324) CH3CN to 64% lOmM NH4CO3H pH 9 solution in water, 36% CH3CN). The desired fractions were collected and concentrated in vacuo to yield product 7 (10 mg, 10%> yield) as yellow oil., 83570-42-7

As the paragraph descriping shows that 83570-42-7 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; MARTINEZ VITURRO, Carlos Manuel; (116 pag.)WO2018/141984; (2018); A1;,
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6298-37-9, Quinoxalin-6-amine is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6298-37-9

Synthesis of 4-propvl-N-quinoxalin-6-vl-benzenesulfonamide, STX 958 (KRB01085) :; To a solution of 4n-propylbenzenesulphonyl chloride (142 mg, 0.651 mmol) in dichloromethane (4 mL) was added pyridine (125 uL, 1.55 mmol) and the mixture was stirred under N2 for 5 min, after which time 6-aminoquinoxaline (90 mg, 0.62 mmol) was added. The resulting mixture was stirred for 4 h at room temperature, then saturated NaHCO3 solution (10 mL) was added and the mixture was extracted into ethyl acetate (20 mL). The organic phase was washed with brine, dried (Na2SO4), filtered and evaporated to give a residue that was purified using flash chromatography to afford an off-white solid (190 mg, 94%), single spot at Rf 0.66 (ethyl acetate). mp 198. 4-198. 9C, HPLC purity 99+% (tR 2. 22 min in 10% water-acetonitrile).’H NMR (CDCI3) : 68. 77 (1H, d, J=1.7 Hz), 8.73 (1H, d, J=1.7 Hz), 8.00 (1H, d, J=8.9 Hz), 7.80 (2H, d, J=8.2 Hz), 7.71 (1 H, d, J=2.5 Hz), 7.59 (1H, dd, J=8.9, 2.5 Hz), 7.23 (2H, obscured under CHCl3), 2.57 (2H, t, J=7.6 Hz), 1.58 (2H, sextet, J=7.5 Hz), 0.87 (3H, t, J=7.4 Hz). LCMS: 326.24 (M- ). FAB-MS (MH+, C17H17N302S) : calcd 328.1119, found 328.1136.

As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.

Reference£º
Patent; STERIX LIMITED; WO2005/42513; (2005); A1;,
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7251-61-8, 2-Methylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7251-61-8, 2-Methyl-quinoxaline (11 g) in a 250 ml round-bottom flask was dissolved with dioxane and heated at 70 C. A mixture of selenium dioxide (8.5 g) with dioxane (29 ml) and water (5.9 ml) was added dropwise into the flask within 90 min. The solution was then stirred at 85 C for 4 h, and then filtered and processed with activated carbon for 30 min. Dioxane was distilled under reduced pressure and the residue was extracted with 30 mL (3 ¡Á 10 mL) ether. Then the combined organic phase was washed with 30 mL wateter (3 ¡Á 10 mL). The ether was dried with MgSO4 at room temperature overnight. The solvent was dried under reduced pressure and the crude product was isolated as brownish solid (9 g). The solid was refluxed with n-hexane for 3 h and heat-filtered after treated with activated carbon for 20 min. Then, n-hexane was distilled to obtain a deep-yellow acicular crystal (48%). 1H-NMR (CDCl3): delta = 7.95 (Ph-H, 2H, m), 8.24 (Ph-H, 2H, m), 9.43 (N=CH, 1H, s), 10.29 (CHO, 1H, s); 13C-NMR(CDCl3):delta = 129.6, 130.4, 131.1, 132.8, 141.9, 142.4, 144.5, 146.0, 192.7; Mp = 106.6-107.2 C.

As the paragraph descriping shows that 7251-61-8 is playing an increasingly important role.

Reference£º
Article; Li, Zongyang; Zhang, Jiaheng; Li, Yubo; Gao, Haixiang; Journal of Molecular Structure; vol. 1035; (2013); p. 69 – 75;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (152 mg, 0.633 mmol) was added to a methylene chloride solution (5.3 ml) of (2S)-1-{4-[(5-ethylpyrimidin-2-yl)oxy]piperidin-1-yl}-3-methyl-1-oxobutan-2-amine dihydrochloride (200 mg, 0.527 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (103 mg, 0.527 mmol), 1-hydroxybenzotriazole monohydrate (85.5 mg, 0.633 mmol) and N-methylmorpholine (0.174 ml, 2.11 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and subsequently the solid substance was collected by filtration to afford the desired title compound (206 mg, yield 82%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.82-12.64 (1H, m), 10.19 (1H, brs), 8.36 (2H, d, J=6.3 Hz), 8.02 (1H, t, J=9.2 Hz), 7.62-7.27 (3H, m), 5.32-5.07 (2H, m), 4.02-3.68 (4H, m), 2.63-2.56 (2H, m), 2.34-1.96 (5H, m), 1.29-1.24 (3H, m), 1.14-1.09 (6H, m). IR (KBr) cm-1: 2965, 1690, 1630, 1525, 1435. MS (ESI, m/z): 479 (M+H)+. HRMS (ESI, m/z): 501.2226 (Calcd for C25H30N6ONaO4: 501.2219). Anal. Calcd for C25H30N6O4: C, 62.75; H, 6.32; N, 17.56. Found: C, 62.78; H, 6.30; N, 17.45.

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
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