1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (152 mg, 0.633 mmol) was added to a methylene chloride solution (5.3 ml) of (2S)-1-{4-[(5-ethylpyrimidin-2-yl)oxy]piperidin-1-yl}-3-methyl-1-oxobutan-2-amine dihydrochloride (200 mg, 0.527 mmol), 3-hydroxyquinoxaline-2-carboxylic acid (103 mg, 0.527 mmol), 1-hydroxybenzotriazole monohydrate (85.5 mg, 0.633 mmol) and N-methylmorpholine (0.174 ml, 2.11 mmol), at room temperature, and stirring was carried out at room temperature overnight. Water was added to the reaction solution, followed by extraction with methylene chloride, and the extract was washed sequentially with a saturated aqueous sodium hydrogencarbonate solution, water and saline, and dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by silica gel column chromatography, the resulting residue was suspended in a mixed solvent of ethanol-diethyl ether, and subsequently the solid substance was collected by filtration to afford the desired title compound (206 mg, yield 82%) as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta: 12.82-12.64 (1H, m), 10.19 (1H, brs), 8.36 (2H, d, J=6.3 Hz), 8.02 (1H, t, J=9.2 Hz), 7.62-7.27 (3H, m), 5.32-5.07 (2H, m), 4.02-3.68 (4H, m), 2.63-2.56 (2H, m), 2.34-1.96 (5H, m), 1.29-1.24 (3H, m), 1.14-1.09 (6H, m). IR (KBr) cm-1: 2965, 1690, 1630, 1525, 1435. MS (ESI, m/z): 479 (M+H)+. HRMS (ESI, m/z): 501.2226 (Calcd for C25H30N6ONaO4: 501.2219). Anal. Calcd for C25H30N6O4: C, 62.75; H, 6.32; N, 17.56. Found: C, 62.78; H, 6.30; N, 17.45.
1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider