With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.
6924-66-9, To a solution of 8-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 2 Intermediate 113), (75.0 mg, 253 mupiiotaomicronIota) in DMF (2.6 ml) was added PyBOP (145 mg, 278 muiotaetaomicronIota), N,N-diisopropylethylamine (180 muIota, 1.0 mmol) and quinoxaline-5-carboxylic acid (44.0 mg, 253 muiotaetaomicronIota) and the reaction was stirred for 16 h at room temperature. For work-up, brine (45 ml) was added and the resulting precipitate was filtrated. The residue was dissolved in DMSO and the crude product was purified by HPLC (Method 6) to give after trituration with water the title product (54 mg)LC-MS (Method 4): Rt = 1 .15 min; MS (ESIpos): m/z = 453 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .548 (5.49), 1 .581 (5.92), 1 .788 (2.48), 1 .820 (5.92), 1 .848 (5.61 ), 1 .901 (6.65), 1 .992 (4.72), 2.001 (4.87), 2.026 (6.99), 2.052 (3.52), 2.124 (6.90), 2.142 (12.41 ), 2.158 (6.99), 2.327 (1 .99), 2.539 (3.37), 2.668 (1 .96), 3.628 (7.72), 3.645 (13.55), 3.662 (7.1 1 ), 4.224 (3.62), 7.293 (2.54), 7.299 (2.85), 7.314 (5.06), 7.321 (5.27), 7.335 (3.13), 7.343 (3.03), 7.485 (5.24), 7.499 (5.85), 7.507 (5.06), 7.521 (4.14), 7.579 (5.33), 7.586 (5.36), 7.600 (5.39), 7.607 (5.00), 7.975 (4.54), 7.995 (7.88), 8.014 (5.33), 8.270 (7.1 1 ), 8.274 (7.05), 8.291 (6.50), 8.295 (6.50), 8.300 (3.92), 8.522 (7.02), 8.526 (6.80), 8.541 (6.59), 9.079 (16.00), 9.087 (15.66), 10.452 (3.80), 10.471 (3.65)
The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider