Day: November 24, 2020

2958-87-4, 2,3,6-Trichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 20 By reaction of 2,3,6-trichloroquinoxaline with propargylamine, following a procedure that is similar to that described in example 2, there is obtained 8-chloro-1-methylimidazo[1,2-a]quinoxaline-4(5H)-one (m.p. >300 C.) and, subsequently, 4,8-dichloro-1-methylimidazo[1,2-a] quinoxaline., 2958-87-4

2958-87-4 2,3,6-Trichloroquinoxaline 18070, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Biomedica Foscama Industria Chimicofarmaceutica S.p.A.; US6124287; (2000); A;,
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49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,49679-45-0

General procedure: Method A: a solution of compound 3 (1.11 g, 4.70 mmol), 3- aminophenol (622 mg, 5.70 mmol) and p-TSA, as a catalyst, in absolute ethanol (40 mL) was refluxed for 110 h. Ethanol was then evaporated under reduced pressure, and the resulting residue was purified by silica column chromatography using cyclohexane with ethyl acetate gradient (0e50%) as eluent to give the desired compound 4a (1.0 g, 69%) as a red powder.

As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Article; Oyallon, Bruno; Brachet-Botineau, Marie; Loge, Cedric; Bonnet, Pascal; Souab, Mohamed; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Berthelot, Pascal; Gouilleux, Fabrice; Viaud-Massuard, Marie-Claude; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 101 – 109;,
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36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Preparation of compound 2a A 25-mL round bottom flask equipped with a magnetic stirrer, a condenser and a nitrogen in/outlet adapter was charged with 2-bromoquinoxaline (100 mg, 0.48 mmol), 4- Fluorophenylboronic acid (80 mg, 0.57 mmol), water/dioxane (1.0 mL/4.0 ml), K2C03 (132 mg, 0.96 mmol). The resulting solution was degassed for 15 min, then Pd(PPh3)4 (27 mg, 0.024 mmol) was added. The reaction mixture was warmed to 100 C and stirred for 1 h. After cooled to room temperature, the reaction mixture was diluted with EtOAc and washed with saturated NaHC03, brine, dried over Na2S04. The organic layer was concentrated under reduced pressure and purified on silica gel. Elution with EtOAc hexanes solvent system afforded the desired compound (40 mg, 38% yield). NMR (400 MHz, CDC13) delta 9.34 (s, 1H), 8.18 (m, 2H), 8.00 (m, 2H), 7.82 (m, 2H), 7.57 (m, 1H), 7.25 (m, 1H).

36856-91-4, The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; PARHI, Ajit; PILCH, Daniel, S.; KAUL, Malvika; WO2013/106756; (2013); A2;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (270 mg, 1.41 mmol), 1-hydroxybenzotriazole monohydrate (150 mg, 1.13 mmol) and N-methylmorpholine (0.410 ml, 3.77 mmol) were added to a methylene chloride solution (10 ml) of the resulting compound (340 mg, 0.940 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (180 mg, 0.940 mmol), at room temperature, under nitrogen stream, and stirring was carried out at room temperature overnight. The reaction solution was washed sequentially with water, a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated, the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Yamazen Corporation, W-Prep 2XY), the residue resulting from concentration was suspended in diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (459 mg, yield 98%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.86 (1H, brs), 9.55 (1H, brs), 7.89 (1H, d, J=8.3 Hz), 7.66 (1H, t, J=7.2 Hz), 7.43-7.37 (2H, m), 7.11-7.06 (1H, m), 6.98-6.93 (1H, m), 6.78-6.73 (1H, m), 4.93 (1H, q, J=7.8 Hz), 4.51-4.43 (1H, m), 3.99-3.87 (2H, m), 3.81 (3H, d, J=6.8 Hz), 3.58-3.45 (2H, m), 2.11-1.84 (3H, m), 1.75-1.49 (2H, m), 0.98 (3H, d, J=6.8 Hz), 0.97 (3H, d, J=6.8 Hz). IR (KBr) cm-1: 2960, 1685, 1640, 1500, 1450, 1215, 1190, 1150, 1030. MS (ESI, m/z): 497 (M+H)+. Anal. Calcd for C26H29FN4O5¡¤1/4H2O: C, 62.33; H, 5.93; N, 11.18; F, 3.79. Found: C, 62.07; H, 6.02; N, 11.04; F, 3.68., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50998-17-9,6-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

50998-17-9, To a stirred solution of compound 1A (0.2 g, 0.79 mmol) and 2-methoxy-6-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine lB (0. 24 g, 1.02 mmol) in 1,4-dioxane (10 mL)/H20 (2 mL) was added K3P04 (0.5 g, 2.36 mmol). The reaction mixture was degassed for 3 mm. and then to it was added the PdC12(dppf)-CH2C12 adduct (0.032 g, 0.03 9 mmol), and the resultant mixture was heated at 100 C for 12 h. The reaction mixture was then filtered through a Celite pad, the filter cake washed with ethyl acetate and the combined filtrate evaporated under reduced pressure to give the cmde compound, which was purified by preparative HPLC (condition N) to yield 6-(6?-methoxy-[2,2?-bipyridinj -3-yl)imidazo [1,2- ajpyridine-3-carbonitrile 17 (0.2 mg, 0.054 mmol, 68.5 % yield). Compound 20B was synthesized by reacting 20A and 2-chloro-3-(4,4,5,5-tetramethyl- 1,3,2-dioxaborolan-2-yl)pyridine (reference: WO 2015157093 Al, WO 2015044172 Al and WO 2014055955 Al) employing the experimental procedure described in Scheme-5 (Method E). The cmde product was purified by silica gel chromatography (40 g RediSep column, eluting with 50 % ethyl acetate in petroleum ether) to yield compound 20B (2.32 g, 9.610 . +mmol, 67.0 /o yield) as alight yellow solid. LCMS: m/z = 242.0 [M+Hj ; ret. time 1.66 mm; condition C.

As the paragraph descriping shows that 50998-17-9 is playing an increasingly important role.

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; DING, Pingyu; GELMAN, Marina; KINSELLA, Todd; SINGH, Rajinder; BHAMIDIPATI, Somasekhar; VELAPARTHI, Upender; BORZILLERI, Robert, M.; RAHAMAN, Hasibur; WARRIER, Jayakumar, Sankara; (232 pag.)WO2016/133838; (2016); A1;,
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Quinoxalinecarboxylic acid (0801-134) (1.0 g, 5.7 mmol, 1.0 eq.)Dissolved in 20 ml of methanol,Add thionyl chloride (1.25 mL, 17.2 mmol, 3.0 equivalents),Heat reflux for 3 hours.Cooled to room temperature, concentrated to dryness under reduced pressure, extracted with ethyl acetate, washed with water, liquid-separated, dried over anhydrous sodium sulfate, filtered concentrated, and concentrated under reduced pressure.After silica gel column chromatography (eluent: eluent: petroleum ether: ethyl acetate = 5:1),The product was obtained as a pale yellow solid, methyl 2-quinoxalinecarboxylate (1.01 g, yield: 93.5percent)., 879-65-2

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
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6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 36 iV-Methyl-iV-tetrahvdro-lH-pyran^-ylquinoxaline–carboxamide To a suspension of quinoxaline-6-carboxylic acid (0.7g, 4 mmol) and N-methyltetrahydro- 2H-pyran-4-amine (0.7 g, mmol), in DMF (6 ml) and dichloromethane (6 ml), were added DMAP (0.49 g, 4 mmol), etaOBT (0.54 g, 4 mmol), NEt3 (1.6 ml) and EDCI (1.26g). The reaction mixture was stirred at room temperature for 4h and then concentrated under vacuum. The crude product was purified on a silica gel column eluting with chloroform/methanol/ triethylamine (95:5:0.5) to give an oil (1.5g) which formed a beige solid upon trituration with dichloromethane/diethyl ether. Mp = 130-131C, LC-MS, MH+ = 272; 1H NMR (300 MHz, CDCl3) delta 8.91 (s, 2H); 8.18 (d, J = 8.4 Hz, IH); 8.11 (s, IH); 7.79 (d, J = 8.4 Hz, IH); 4.95- 3.50 (m, 5H); 3.07 and 2.91 (s + s, 3H); 2.02-1.65 ppm (m, 4H)., 6925-00-4

The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/143963; (2008); A1;,
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1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (184 mg, 0.530 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (104 mg, 0.530 mmol) to afford the desired title compound (134 mg, yield 49%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.84 (1H, brs), 9.56 (1H, m), 7.87 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.8 Hz), 7.30 (2H, d, J=8.6 Hz), 7.11 (2H, dd, J=8.6 Hz, 5.0 Hz), 5.00 (1H, m), 4.69 (1H, m), 4.08-3.79 (2H, m), 3.58-3.20 (2H, m), 2.10-1.46 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2945, 1685, 1640, 1505, 1240. MS (ESI, m/z): 519 (M+H)+. HRMS (ESI, m/z): 519.1850 (Calcd for C25H26F3N4O5: 519.1855).

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.

[0175] To a solution of quinoxaline-6-carboxylic acid (5.1 g, 29.3 mmol, 1.0 eq) in DMF (100 mL) was added HATU (13.3 g, 35 mmol. 1.2 eq), DIEA (20 mL, 117.2 mmol, 4.0 eq) and Omicron,Nu- Dimethyl-hydroxylamine hydrochloride salt (3.38 g, 35 mmol, 1.2 eq). The mixture was stirred at r.t. overnight, then the solvent was evaporated. The residue was purified via flash column (PE/EA = 2/1, v/v) to afford N-meth (5.1 g, 80 %).

6925-00-4, 6925-00-4 Quinoxaline-6-carboxylic acid 674813, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/43935; (2013); A1;,
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50998-17-9, 6-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50998-17-9, To a flask including 1 eq. of triphenylen-2-ylboronic acid and 1.2 eq. of 6-bromoquinoxaline, 0.03 eq. of Pd(dba)3, 0.06 eq. of (t-Bu)3P, and toluene (1 M) were added and refluxed with stirring for about 12 hours. Then, the reaction product was cooled to ambient temperature, extracted with methylene chloride and washed with distilled water. The product thus obtained was dried with MgSO4 and distilled under a reduced pressure, and the residue was separated by column chromatography to produce Compound B-1 (Yield 80.4%). The compound thus produced was identified using a high resolution mass spectrometer and 1H NMR. The mass of the synthesized compound thus identified was 355. [HRMS for C26H16N2 [M]+: calcd: 356.43, found: 355, Elemental Analysis for C26H16N2 calcd: C, 87.62; H, 4.52; N, 7.86].

50998-17-9 6-Bromoquinoxaline 610939, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; SAMSUNG DISPLAY CO., LTD.; JEONG, Hyein; LEE, Jungsub; (58 pag.)US2017/162796; (2017); A1;,
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