The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.
6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 36 iV-Methyl-iV-tetrahvdro-lH-pyran^-ylquinoxaline–carboxamide To a suspension of quinoxaline-6-carboxylic acid (0.7g, 4 mmol) and N-methyltetrahydro- 2H-pyran-4-amine (0.7 g, mmol), in DMF (6 ml) and dichloromethane (6 ml), were added DMAP (0.49 g, 4 mmol), etaOBT (0.54 g, 4 mmol), NEt3 (1.6 ml) and EDCI (1.26g). The reaction mixture was stirred at room temperature for 4h and then concentrated under vacuum. The crude product was purified on a silica gel column eluting with chloroform/methanol/ triethylamine (95:5:0.5) to give an oil (1.5g) which formed a beige solid upon trituration with dichloromethane/diethyl ether. Mp = 130-131C, LC-MS, MH+ = 272; 1H NMR (300 MHz, CDCl3) delta 8.91 (s, 2H); 8.18 (d, J = 8.4 Hz, IH); 8.11 (s, IH); 7.79 (d, J = 8.4 Hz, IH); 4.95- 3.50 (m, 5H); 3.07 and 2.91 (s + s, 3H); 2.02-1.65 ppm (m, 4H)., 6925-00-4
The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/143963; (2008); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider