1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (270 mg, 1.41 mmol), 1-hydroxybenzotriazole monohydrate (150 mg, 1.13 mmol) and N-methylmorpholine (0.410 ml, 3.77 mmol) were added to a methylene chloride solution (10 ml) of the resulting compound (340 mg, 0.940 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (180 mg, 0.940 mmol), at room temperature, under nitrogen stream, and stirring was carried out at room temperature overnight. The reaction solution was washed sequentially with water, a saturated aqueous sodium hydrogencarbonate solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated, the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Yamazen Corporation, W-Prep 2XY), the residue resulting from concentration was suspended in diethyl ether, and the solid substance was collected by filtration to afford the desired title compound (459 mg, yield 98%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.86 (1H, brs), 9.55 (1H, brs), 7.89 (1H, d, J=8.3 Hz), 7.66 (1H, t, J=7.2 Hz), 7.43-7.37 (2H, m), 7.11-7.06 (1H, m), 6.98-6.93 (1H, m), 6.78-6.73 (1H, m), 4.93 (1H, q, J=7.8 Hz), 4.51-4.43 (1H, m), 3.99-3.87 (2H, m), 3.81 (3H, d, J=6.8 Hz), 3.58-3.45 (2H, m), 2.11-1.84 (3H, m), 1.75-1.49 (2H, m), 0.98 (3H, d, J=6.8 Hz), 0.97 (3H, d, J=6.8 Hz). IR (KBr) cm-1: 2960, 1685, 1640, 1500, 1450, 1215, 1190, 1150, 1030. MS (ESI, m/z): 497 (M+H)+. Anal. Calcd for C26H29FN4O5¡¤1/4H2O: C, 62.33; H, 5.93; N, 11.18; F, 3.79. Found: C, 62.07; H, 6.02; N, 11.04; F, 3.68., 1204-75-7
As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider