Month: November 2020

67074-63-9, 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67074-63-9

24c. 1,2,3,4-tetrahydroquinoxaline To a solution of 24b (300 mg, 1.85 mmol) in THF (2 mL) was added 1N LiAlH4 (10 mL, 10 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was quenched with H2O (1 mL) at 0 C., 15% NaOH (1 mL), followed by H2O (1 mL). The reaction mixture was extracted with EtOAc. The EtOAc was then washed with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24c (260 mg, 95%) as white powder. LC-MS ESI m/z 149 [M+H]+.

67074-63-9 4-Methyl-3,4-dihydroquinoxalin-2(1H)-one 12938663, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
Quinoxaline – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-34-8,6-Bromoquinoxalin-2(1H)-one,as a common compound, the synthetic route is as follows.

55687-34-8, Compound 39 (600 mg, 2.66 mmol) was added to cold phosphorous oxychloride (4 mL) in portions wise to give a slurry. To the resulting slurry was added drop wise N,N- dimethylaniline (0.4 ml, 2.93 mmol) below 15C. The brick red mixture was refluxed for 15 min, and the resulting dark brown clear solution was then cooled to ambient temperature. It was added to ice cold water (40 mL) , and the mixture was basified slowly with 40% aq. NaOH to pH 8. The solid was collected by filtration, washed with water (2×10 mL) and dried to give the title compound 40 (70%) .

The synthetic route of 55687-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro; BARAWKAR, Dinesh; BONAGIRI, Rajesh; KHOSE, Goraksha; SHINDE, Shailesh; (226 pag.)WO2016/199943; (2016); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.

A slurry of 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-(7-azaspiro[3.5]non-1-en-2-yl)isoxazole (25 mg, 0.07 mmol, synthesis described in General Method A), 6-bromo-2-chloroquinoxaline (19.5 mg, 0.08 mmol) and Cs2CO3 (43.4 mg, 0.13 mmol) in dioxane (0.3 mL) was degassed by bubbling nitrogen through the mixture for 5 minutes. Chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) (RuPhos-Pd-G2) (2.59 mg, 3.33 mumol) was added and the reaction mixture was sealed and heated to 90C. for 6 hours. The crude reaction mixture purified directly by flash chromatography on SiO2 (0-100% EtOAc/hexanes, Isco 12 g column) to yield 4-(7-(6-bromoquinoxalin-2-yl)-7-azaspiro[3.5]non-1-en-2-yl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (26 mg, 0.04 mmol, 64% yield) as a gum. 1H NMR (400 MHz, CDCl3) delta 8.57 (s, 1H), 8.03 (d, J=2.2 Hz, 1H), 7.64 (dd, J=8.8, 2.2 Hz, 1H), 7.53 (d, J=8.8 Hz, 1H), 7.46-7.42 (m, 2H), 7.40-7.34 (m, 1H), 5.80 (s, 1H), 3.94 (dt, J=13.5, 5.1Hz, 2H), 3.66-3.50 (m, 2H), 2.44 (s, 2H), 2.21 (tt, J=8.4, 5.1Hz, 1H), 1.76 (t, J=5.6 Hz, 4H), 1.36-1.30 (m, 2H), 1.22-1.15 (m, 2H)., 55687-02-0

Big data shows that 55687-02-0 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Carpenter, Joseph E.; Huang, Yanting; Wang, Ying; Wu, Gang; (137 pag.)US2019/127362; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 10 2-(Aminoiminomethylthio)-3-quinoxalinecarboxylic acid ethyl ester, hydrochloride 2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (9.5 g., 0.04 mole) and 3.052 g. (0.04 mole) of thiourea were dissolved in 200 ml. of acetone. The solution was boiled in an open flask for 11/2 hours during which acetone was added to maintain the volume at 200 ml. The reaction mixture was cooled and the solid was collected by filtration to give 7.8 g. of crude product. Recrystallization from methanol-acetone afforded 3.55 g. of off-white solid, over wide range dec. Analysis for: C12 H13 ClN4 O2 S Calculated: C, 46.08; H, 4.19; N, 17.91; Cl, 11.33; S, 10.25. Found: C, 46.01; H, 4.13; N, 17.85; Cl, 11.38; S, 10.32. An additional 4.05 g. of product was recovered from the reaction mixture to give a total yield of 7.60 g. (59.3%). Found: C, 46.06; H, 4.14; N, 17.79; Cl, 11.38; S, 10.37

49679-45-0, As the paragraph descriping shows that 49679-45-0 is playing an increasingly important role.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), hydrazine hydrate90% (0.07 mL, 1.5 mmol) was added and the reaction mixture was stirred in an ice bath at 0 C for 2 h.After completion of the reaction, the precipitate that formed was filtered, dried and the crude productwas further purified by a silica gel column chromatography (chloroform) to give the product. Yield:61%; (red-brown powder): mp 201-203 C; IR (KBr) max in cm1: 3415, 3250, 3146 (NH2, NH), 1598(C=N); 1H-NMR (DMSO-d6): 5.00 (s, br, 2H, NH2; exchangeable with D2O), 7.37-7.79 (m, 3H, Ar-H),9.16 (s, br, 1H, NH; exchangeable with D2O); 13C-NMR (DMSO-d6): 124.68, 129.67, 130.02, 134.78,138.98, 140.60 (6Ar-C), 145.22, 145.85, (2C=N); MS (m/z), 64 (M+ C4H4BrClN3; 100%), 272 (M+; 5%),273 (M+ + 1; 21%), 274 (M+ + 2; 17%), 275 (M+ + 3; 3%), 276 (M+ + 4; 5%). Anal. Calcd. for C8H6BrClN4(273.52): C, 35.13; H, 2.21; N, 20.48%. Found: C, 34.97; H, 2.45; N, 20.34%.

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
Quinoxaline – Wikipedia
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879-65-2, 2-Quinoxalinecarboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,879-65-2

The compound [IILA2-3] is formed by coupling 5- [1-amino-2- (3-fluorophenyl)- ethyl]-3- (3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt, (IVa2-2) and quinoxaline-2-carboxylic acid or quinoxaline-2-carbonylchloride as shown in step 3 of Scheme 1. This coupling reaction is generally conducted at a temperature from [ABOUT-30C] to about [80C,] preferably from about [0C] to about [25C.] The coupling reaction may occur with a coupling reagent that activates the acid functionality. Exemplary coupling reagents include dicyclohexylcarbodiimide/hydroxybenzotriazole (DCC/HBT), N-3-dimethylaminopropyl-N’-ethylcarbodiimide (EDC/HBT), [2-ETHYOXY-1-] ethoxycarbonyl-1, 2-dihydroquinoline (EEDQ), carbonyl diimidazole (CDI)/dimethylaminopyridine (DMAP), and diethylphosphorylcyanide. The coupling is conducted in an inert solvent, preferably an aprotic solvent, such as [ACETONITRILE,] [DICHLOROMETHANE,] chloroform, or N, N-dimethylformamide. One preferred solvent is methylene chloride. In one embodiment, quinoxaline acid is combined with methylene chloride, oxalyl chloride and a catalytic amount of N, N-dimethylformamide to form an acid chloride complex. The compound IVa2-2 is added to the acid chloride complex followed by triethylamine at a temperature from about [0C] to about [25C] to form the compound [ILLA2-3.]

879-65-2 2-Quinoxalinecarboxylic acid 96695, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2004/14875; (2004); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under the protection of nitrogen,Weighing compound S5 (15 mmol), S17 (15 mmol), [Pd2(dba)3]¡¤CHCl3(0.3 mmol) and HP(tBu)3¡¤BF4 (0.6 mmol),Add to a 100 mL two-necked flask.Inject 30 mL of toluene into the two-necked flask (pre-pass N2 for 15 min to remove oxygen).Then, 3.6 mL of a 1 M aqueous solution of K2CO3 (previously passed N2 for 15 min to remove oxygen) was added dropwise, and stirred at room temperature overnight.After the reaction was over, 50 mL of deionized water was added.Then add a few drops of 2M HCl. Extract with dichloromethane.Collect organic phase,It was dried over anhydrous Na2SO4.Filter the dried solution,The solvent was removed using a rotary evaporator to give a crude material.The crude product was purified by silica gel column chromatography.Final purification gave solid P4 (13.2 mmol, 88%)., 36856-91-4

As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Tianma Organic Shine Display Co., Ltd.; Gao Wei; Wang Xiangcheng; Zhang Lei; Niu Jinghua; (47 pag.)CN108358905; (2018); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

59564-59-9, 3,4-Dihydroquinoxalin-2(1H)-one is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59564-59-9, 24b. 4-methyl-3,4-dihydroquinoxalin-2(1H)-one To a solution of 24a (500 mg, 3.378 mmol) in MeOH (3 mL) was added NaBH3CN (425 mg, 6.76 mmol), paraformaldehyde (102 mg), followed by HOAc (30 muL). The reaction mixture was stirred at rt for 4 h. Another portion of NaBH4CN (212 mg, 3.37 mmol) and parafornaldehyde (51 mg) were added to the reaction mixture along with conc. HCl (10 muL). The reaction mixture was stirred at 50 C. for 5 h and cooled to rt. The pH was adjusted to 8 and the solvent was evaporated under reduced pressure. The desired product was extracted into EtOAc and washed it with brine, dried over Na2SO4. The solvent was evaporated under reduced pressure to afford 24b (537 mg, 98%) as beige powder. LC-MS ESI m/z 163 [M+H]+.

As the paragraph descriping shows that 59564-59-9 is playing an increasingly important role.

Reference£º
Patent; Tuerdi, Huji; Chao, Hannguang J.; Qiao, Jennifer X.; Wang, Tammy C.; Gungor, Timur; US2005/261244; (2005); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

49679-45-0, Ethyl 3-chloroquinoxaline-2-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 16 2-[(Butylamino)(butylimino)methylthio]-3-quinoxalinecarboxylic acid ethyl ester, hydrochloride 2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (7.10 g., 0.03 mole) was dissolved in 125 ml. of acetone treated with Norit and filtered. The filtrate was added to 5.650 g. (0.03 mole) of 1,3-di-n-butylthiourea in 100 ml. of acetone. The solution was stirred at reflux under a nitrogen atmosphere for 6 hours, allowed to cool to room temperature, and stirred an additional 17 hours. The red solution was treated with Norit, filtered, and concentrated to a volume of 100 ml. The yellow solid that crystallized out was collected by filtration, washed and dried to give the 6.05 g. (47.5% yield) of product, m.p. 138-139 C. (dec.). Analysis for: C20 H29 ClN4 O2 S Calculated: C, 56.52; H, 6.88; N, 13.18; Cl, 8.34. Found: C, 56.74; H, 6.78; N, 13.25; Cl, 8.09.

49679-45-0, The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; American Home Products Corporation; US4349674; (1982); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.

Under nitrogen protection,The diprazole pyrene intermediate 100 mmol,2-bromoquinoxaline 223 mmol,Tris (dibenzylideneacetone) dipalladium 5.0 mmol,Sodium tert-butoxide,Tri-tert-butylphosphine (20.1 mmol) was placed in a reaction vessel,And dissolved in 500 ml of toluene,110 reflux reaction 24h,The reaction end point was determined by thin layer chromatography (TLC)After completion of the reaction, the mixture was cooled to room temperature, passed through a silica gel funnel, washed with methylene chloride, spin dried, recrystallized from dichloromethane / petroleum ether,After drying, 81 mmol of compound 15 was obtained in 81% yield.

36856-91-4, As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.

Reference£º
Patent; Shanghai Keliente Chemical Materials Co., Ltd.; Yin Enxin; Lin Wenjing; (17 pag.)CN104262347; (2017); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider