An article , which mentions 25983-13-5, molecular formula is C8H4Cl2N2O2. The compound – 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione played an important role in people’s production and life., 25983-13-5
Synthesis and antimicrobial evaluation of novel sulphur bridged 2-oxo-1,2,3,4-tetrahydropyrimidine derivatives
In this study, novel series of eleven 2-oxo-6-(4-pyridin-4-yl-thiazol-2-yl sulfanylmethyl)-1,2,3,4-tetrahydropyrimidine derivatives (3a-k) was synthesized by reacting 4-(pyridin-4-yl)-1, 3-thiazol-2-thiol (1) and ethyl-4-chloroacetocetate in dimethylformamide. To this reaction mixture, anhydrous potassium carbonate was added and the reaction mixture stirred at room temperature afforded ethyl 3-oxo-4-[(4-pyridin-4-yl-1,3-thiazol-2-yl)thio]butanoate (2) as intermediate. This on subsequent treatment with urea and substituted aryl aldehyde afforded the titled compounds (3a-k). The structural features of the synthesized compounds were characterized by elemental, IR, 1H NMR, 13C NMR and Mass spectral analysis. All the compounds were evaluated for their antimicrobial activity against four bacterial strains (E. coli, S. aureus, K. pneumonia and B. subtilis) and two fungal strains (C. albicans and A. Niger). Docking studies were also performed against glucosamine-6-phosphate synthase enzyme in order to study the putative binding mode of the active compounds.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1847 | ChemSpider