Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Friis, Stig D. and a compound is mentioned, 1448-87-9, 2-Chloroquinoxaline, introducing its new discovery. 1448-87-9
A Dual Palladium and Copper Hydride Catalyzed Approach for Alkyl?Aryl Cross-Coupling of Aryl Halides and Olefins
We report an efficient means of sp2?sp3 cross coupling for a variety of terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis. In addition to its applicability to a range of aryl bromide substrates, this process was also suitable for electron-deficient aryl chlorides, furnishing higher yields than the corresponding aryl bromides in these cases. The optimized protocol does not require the use of a glovebox and employs air-stable Cu and Pd complexes as precatalysts. A reaction on 10 mmol scale further highlighted the practical utility of this protocol. Employing a similar protocol, a series of cyclic alkenes were also examined. Cyclopentene was shown to undergo efficient coupling under these conditions. Lastly, deuterium-labeling studies indicate that deuterium scrambling does not take place in this sp2-sp3 cross coupling, implying that beta-hydride elimination is not a significant process in this transformation.
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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N584 | ChemSpider