Day: December 14, 2020

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. 55686-94-7. Introducing a new discovery about 55686-94-7, Name is 2-Chloro-7-nitroquinoxaline

From simple quinoxalines to potent oxazolo[5,4-: F] quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)

2,7-Disubstituted oxazolo[5,4-f]quinoxalines were synthesized from 6-amino-2-chloroquinoxaline in four steps (iodination at C5, substitution of the chloro group, amidation and copper-catalysed cyclization) affording 28 to 44% overall yields. 2,8-Disubstituted oxazolo[5,4-f]quinoxaline was similarly obtained from 6-amino-3-chloroquinoxaline (39% overall yield). For the synthesis of other oxazolo[5,4-f]quinoxalines, amidation was rather performed before substitution; moreover, time-consuming purification steps were avoided between the amines and the final products (38 to 54% overall yields). Finally, a more efficient method involving merging of the last two steps in a sequential process was developed to access more derivatives (37 to 65% overall yields). Most of the oxazolo[5,4-f]quinoxalines were evaluated for their activity on a panel of protein kinases, and a few 2,8-disubstituted derivatives proved to inhibit GSK3 kinase. While experiments showed an ATP-competitive inhibition on GSK3beta, structure-activity relationships allowed us to identify 2-(3-pyridyl)-8-(thiomorpholino)oxazolo[5,4-f]quinoxaline as the most potent inhibitor with an IC50 value of about 5 nM on GSK3alpha.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1736 | ChemSpider

32601-86-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.32601-86-8, Name is 2-Chloro-3-methylquinoxaline, molecular formula is C9H7ClN2. In a Article, authors is Singh£¬once mentioned of 32601-86-8

Synthesis and antimicrobial activity of some new thioether derivatives of quinoxaline

2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1045 | ChemSpider

23088-23-5, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 23088-23-5, name is Methyl 6-Quinoxalinecarboxylate. In an article£¬Which mentioned a new discovery about 23088-23-5

Structural requirements for potential Na/H exchange inhibitors obtained from quantitative structure-activity relationships of monocyclic and bicyclic aroylguanidines.

The quantitative structure-activity relationship (QSAR) of N-(3-amino-6-chloro-5-ethylisopropylaminopyrazine-4-carbonyl) guanidine (EIPA) 1ac and its derivatives as Na/H exchange inhibitors was analyzed using th steric parameters and an indicator variable. The results indicated that bicyclic aroylguanidines might have Na/H exchange inhibitory activity. Therefore, various bicyclic aroylguanidines were synthesized and tested for Na/H exchange inhibitory activity. The QSAR study of the bicyclic aroylguanidines showed that hydrophobic bicyclic rings seemed to be preferable for potent activity. The hydrophobicity of the aroyl ring moiety was thought to be particularly important. Thus, the QSAR of EIPA and its derivatives was re-analyzed using hydrophobicity and steric parameters. The results indicated that high hydrophobicity of the pseudo-ring moiety and a substituent of appropriate length at the position corresponding to the 5-position of the naphthalene ring enhance the activity. As expected from the results, 5-bromo-2-naphthoylguanidine 3b and 5-methoxy-2-naphthoylguanidine 3c exhibited strong activity. These findings will be helpful to design new, potent Na/H exchange inhibitors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 23088-23-5 is helpful to your research. 23088-23-5

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1098 | ChemSpider

In an article, published in an article,authors is Bhilare, Shatrughn, once mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline,molecular formula is C8H5ClN2, is a conventional compound. this article was the specific content is as follows. 1448-87-9

Pd/PTABS: Low Temperature Etherification of Chloroheteroarenes

A mild, general, and highly efficient catalytic etherification protocol for chloroheteroarenes was developed using the Pd/PTABS catalytic system. The protocol is selective for the etherification of chloroheteroarenes using a large variety of electron-rich and electron-deficient phenol bearing synthons which include inter alia biologically and commercially important estrone, estradiol, tyrosine, and several other molecules. The mildness of the new protocol is expected to be beneficial for the synthesis of complex drugs and drug intermediates offering late-stage modification of bioactive compounds.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N529 | ChemSpider

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 15804-19-0, Name is Quinoxaline-2,3(1H,4H)-dione, molecular formula is C8H6N2O2, 15804-19-0, In a Article, authors is Nikam£¬once mentioned of 15804-19-0

AMPA receptor antagonists

AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury. However, poor physical properties have been a major limiting factor in developing these as viable drug candidates. The quinoxaline-2,3-dione template has been the backbone of various competitive AMPA receptor antagonists such as NBQX, PNQX, YM-90K and more recently ZK200775. The SAR learned from these have been valuable for developing the AMPA pharmacophore model (Fig. 2) and has been discussed in detail in this review. There have been efforts in this area to design very selective AMPA receptor antagonists by minimizing the interaction at the NMDA associated GlyN receptors. Compounds designed by BASF and Yamanouchi have been successful in these efforts and their compounds show excellent affinity for the AMPA receptors. Efforts by Warner-Lambert and Novartis also highlight significant success in developing balanced AMPA and GlyN receptor antagonists. Non-competitive AMPA receptor antagonists are also being pursued for various neurological disorders including neuroprotection and are divided in two major classes, viz. positive and negative allosteric modulators. The physical properties of negative allosteric modulators such as GYK1 52466, which belong to the 2,3-benzodiazepinyl structural class have been significantly better. However, the in vitro activity of these compounds has been in the micromolar range and the overall class has the disadvantage of not having a high throughput assay. Other classes of compounds such as phthalazines and quinazolines are being developed and have raised hopes for the second generation of compounds in this area.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N366 | ChemSpider

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Review, the author is Fomina, Marina V. and a compound is mentioned, 2213-63-0, 2,3-Dichloroquinoxaline, introducing its new discovery. 2213-63-0

Modern approaches to the synthesis and prospects for the use of cyanine dyes containing functional groups in the N-substituents

Methods for the synthesis of mono-, tri-, penta-and heptamethine cyanine dyes containing functional groups in N-substituents are considered. Approaches suitable for the preparation of both symmetrical and unsymmetrical cyanine dyes are presented. Examples of the practical use of this type of cyanine dyes as fluorescent labels and probes in biology and medicine, as well as of components of photoactive supramolecular structures, photosensitizers and photo-and electroluminescent materials are given.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1329 | ChemSpider

18514-76-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.18514-76-6, Name is 5-Nitroquinoxaline, molecular formula is C8H5N3O2. In a Article, authors is Sanz, Roberto£¬once mentioned of 18514-76-6

Bronsted acid catalyzed alkylation of indoles with tertiary propargylic alcohols: Scope and limitations

Direct alkylation of indoles with a wide variety of tertiary propargylic alcohols under Bronsted acid catalysis conditions has been studied. A general and environmentally friendly method for the synthesis of 3-propargylated indoles with quaternary carbon atoms at their propargylic positions has been developed. The reactions are highly regioselective with regard both to the indole and to the alkynol components. Only with N-unsubstituted 2-arylindoles do competitive SN? reactions take place to afford 3-dienyl- or 3-allenylindoles, depending on the alkynol moiety. The reactions were carried out in air with undried solvents, and water was the only side product. Treatment of indoles with tertiary propargylic alcohols in the presence of Bronsted acid catalysts provided 3-propargylindoles with quaternary centers at their propargylic positions. In addition, 3-dienyl- and 3-allenylindoles could also be obtained with convenient substitution in the indole and alkynol components. The reactions needed no special precautions, and water was the only side product. Copyright

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N906 | ChemSpider

2213-63-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article, authors is Poradowska, Henryca£¬once mentioned of 2213-63-0

The Mass Spectra of Halogeno Derivatives of Quinoxaline

The mass spectra of seventeen different quinoxaline halogeno derivatives are reported.The fragmentation mechanism is discussed.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1506 | ChemSpider

1448-87-9, Name is 2-Chloroquinoxaline, belongs to quinoxaline compound, is a common compound. 1448-87-9In an article, authors is Armengol, once mentioned the new application about 1448-87-9.

Synthesis of thieno[2,3-b]quinoxalines and pyrrolo[1,2-a]-quinoxalines from 2-haloquinoxalines

The palladium(0)-catalysed coupling of 2-haloquinoxalines with functionally substituted alkynes, addition of one mol equivalent of bromine to the 2-alkynylquinoxalines thus produced and then reaction of the resulting dibromides with disodium trithiocarbonate produced 2-hydroxymethyl- and 2-(diethoxymethyl)thieno[2,3-b]quinoxalines. Addition of bromine to some 6-substituted-2-(3,3-diethoxypropyn-1-yl)quinoxalines gave pyrrolo[1,2-a]quinoxalines. Treatment of a 3-(1,2-dibromoalkenyl)quinoline, a 3-(1,2-dibromoalkenyl)pyrazine, and a 5-(1,2-dibromoalkenyl)-pyrimidine with disodium trithiocarbonate failed to induce thiophene ring formation.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N517 | ChemSpider

2213-63-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article, authors is Nasr, Magda N.£¬once mentioned of 2213-63-0

Synthesis and anticonvulsant activity of novel 2- and 3-[4-(trisubstituted pyridyl)-phenylamino]- and 2-[3- and 4-(trisubstituted pyridyl)-phenoxy]-quinoxaline derivatives

A series of novel quinoxaline derivatives linked to a pyridine moiety through phenylamino or phenoxy residue was synthesized and evaluated as candidate anticonvulsants. The synthesis was achieved through reaction of 2,3-dichloroquinoxaline (1) with an equimolar amount of 4-aminoacetophenone to give compound 2 which is considered as an important synthon for the construction of a pyridine ring via several synthetic routs. Some compounds were synthesized through formation of the intermediate alpha,beta-unsaturated compounds which, in turn, were allowed to react with malononitrile to give the corresponding alkoxypyridines (8-17). Compounds 18-21 were synthesized by a one-pot simple reaction between 2, the appropriate aldehyde, and malononitrile in sodium alkoxide solution. Moreover, they can be synthesized through reaction of compound 2 and arylidenemalononitrile in sodium alkoxide. The phenoxy analogues were prepared by reaction of 1 with 4-hydroxyacetophenone or 3-hydroxybenzaldehyde to give 22 and 27, respectively. These compounds, in turn, were allowed to react with malononitrile and the proper carbonyl compound in presence of sodium alkoxide in a one-pot reaction technique to give the target compounds. Biological evaluation of the prepared compounds showed that some of them are potent anticonvulsant agents. The detailed synthesis, spectroscopic and biological data are reported.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1482 | ChemSpider