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Discovery and Structure-Activity Relationship of a Series of 1-Carba-1-dethiacephems Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus
The synthesis and antimicrobial activity of several new 1-carba-1-dethiacephalosporins is described.The discovery of unique activity of some of the analogues against methicillin-resistant Staphylococcus aureus led to the development of a structure-activity relationships designed to optimize this activity.The results of this investigation along with the pharmacokinetic characteristics of select compounds are described.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1852 | ChemSpider