Reference of 41959-35-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.41959-35-7, Name is 6-Nitro-1,2,3,4-tetrahydroquinoxaline, molecular formula is C8H9N3O2. In a Article£¬once mentioned of 41959-35-7
High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery
Cysteine-reactive small molecules are used as chemical probes of biological systems and as medicines. Identifying high-quality covalent ligands requires comprehensive kinetic analysis to distinguish selective binders from pan-reactive compounds. Quantitative irreversible tethering (qIT), a general method for screening cysteine-reactive small molecules based upon the maximization of kinetic selectivity, is described. This method was applied prospectively to discover covalent fragments that target the clinically important cell cycle regulator Cdk2. Crystal structures of the inhibitor complexes validate the approach and guide further optimization. The power of this technique is highlighted by the identification of a Cdk2-selective allosteric (type IV) kinase inhibitor whose novel mode-of-action could be exploited therapeutically.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 41959-35-7
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1074 | ChemSpider