Electric Literature of 15804-19-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 15804-19-0, Quinoxaline-2,3(1H,4H)-dione, introducing its new discovery.
Structure-activity relationships in a series of 3-sulfonylamino-2-(1H)-quinolones, as new AMPA/kainate and glycine antagonists
This paper describes the design and synthesis of a new class of molecules, the 3-sulfonylamino-2-(1H)-quinolones, which are potent and selective antagonists at both the AMPA/kainate site as well as at the NMDA-associated glycine site. The molecules were characterized by their binding affinities to rat cortical membranes and by electrophysiology on Xenopus oocytes injected with mRNA isolated from rat cerebral cortex. The most potent compound 61 has an IC50 of 0.09 muM for binding at the AMPA/kainate site, and 0.16 muM in oocyte electrophysiology.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 15804-19-0. In my other articles, you can also check out more blogs about 15804-19-0
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N301 | ChemSpider