Archives for Chemistry Experiments of 2,3-Dichloroquinoxaline

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Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Synthesis of Imidazo<2,1-b>-benzothiazoles and Quinoxalino<2',3':4,5>imidazo<2,1-b>benzothiazoles

2-Amino-6-t-butyl-4,5,6,7-tetrahydrobenzothiazole (II), obtained from 4-t-butylcyclohexanone and thiourea, on condensation with alpha-haloketones in benzene gives the ketones III which undergo cyclization in hot ethanol to give imidazo<2,1-b>benzothiazoles (IV).Compounds IV have also been obtained in one-step by heating II with alpha-haloketones in ethanol.II on treatment with 2,3-dichloroquinoxaline and chloroacetic acid yields in one-step quinoxalino<2',3':4,5>imidazo<2,1-b>benzothiazole (V) and imidazo<2,1-b>benzothiazol-3(2H)-one (VI), respectively.The anthelmintic, antibacterial and antifungal activities of IV and V have been evaluated.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1453 | ChemSpider

Extended knowledge of Quinoxaline-6-carboxylic acid

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CERTAIN CHEMICAL ENTITES, COMPOSITIONS, AND METHODS

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described

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Some scientific research about 2213-63-0

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2213-63-0, name is 2,3-Dichloroquinoxaline, introducing its new discovery. Application In Synthesis of 2,3-Dichloroquinoxaline

Synthesis of Pyrido<1',2':1,2>imidazo<4,5-b>quinoxalines

Synthesis of pyrido<1',2':1,2>imidazo<4,5-b>quinoxalines by the facile cyclizations of 2,3-dichloroquinoxalines with 2-aminopyridines and of 2-amino-3-chloroquinoxalines with various substituted pyridines is described.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1572 | ChemSpider

Discovery of 49679-45-0

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Synthesis of 2-(Quinoxalin-2-ylamino-benzotriazolyl) Pentanedioic Derivatives as Potential Anti-Folate Agents

Anti-folate agents had a significant impact on therapeutic treatment plans for diseases such as cancer, and bacterial and parasitic infections, notably malaria. Quinoxaline derivatives showed in vitro anticancer activity and were able to inhibit both the dihydrofolate reductase and thymidylate synthase. Here, we decided to combine the chemical properties of quinoxalines and quinoxaline 1,4-dioxides with those of benzotriazole nucleus with the aim to evaluate the resulting biological properties. Two main new series, including more than 60 compounds, were prepared. In the first one, the benzotriazole moiety was linked through the nitrogen atoms 1, 2, or 3, to a glutaric acid substituent to simulate a glutamic moiety. In the second series, the glutaric acid was substituted with acetic acid moiety to evaluate the effects of steric hindrance. Here, we describe the multistep chemical processes to obtain all titled quinoxalines starting from commercially available diamines. The classical oxidation of selected quinoxalines was unsuccessful, and we have come to an independent synthetic pathway to obtain new derivatives linked to the benzotriazole moieties starting from synthons bearing N-oxide functionality.

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Current applications of the sonogashira reaction in the synthesis of heterocyclic compounds: An update

The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds.?The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.

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Discovery of 2-Chloro-6-methoxyquinoxaline

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3-Isopropylidenemalic acid: A mechanism-based inhibitor of 3-isopropylmalate dehydrogenase

3-Isopropylidenemalic acid (1) was designed and synthesized as an inhibitor of 3-isopropylmalate dehydrogenase (IPMDH). While being weakly active as substrate, 1 appeared to be a mechanism-based inhibitor (K1 = 60.2 muM) for IPMDH as deduced from the time-dependent and kinetic analyses.

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Quinoxaline – Wikipedia,
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The Absolute Best Science Experiment for 32601-86-8

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A FACILE SYNTHESIS OF NOVEL TRICYCLIC COMPOUNDS, TETRAZOLOQUINOXALINES AND 1,2,4-TRIAZOLOQUINOXALINES

Novel 5-methyltetrazolo<1,5-a>quinoxalin-4-ones (5) and 5-methyl-1,2,4-triazolo<4,3-a>quinoxalin-4-ones (7) could be synthesized from 1-methyl-3-chloroquinoxalin-2-ones (3) and 1-methyl-3-hydrazinoquinoxalin-2-ones (6), respectively.Further extensive study was carried out to synthesize 4- or 7- substituted and 4,7-disubstituted tetrazolo<1,5-a>quinoxalines (10) and 1,2,4-triazolo<4,3-a>quinoxalines (12).

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Discovery of 2213-63-0

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NOVEL QUINOXALINE INHIBITORS OF PI3K

The invention provides methods that relate to a novel therapeutic strategy for the treatment of cancer and inflammatory diseases. In particular, the method comprises administration of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such compound admixed with at least one pharmaceutically acceptable excipient

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The unexpected and facile molybdenum mediated formation of tri- and tetracyclic pentathiepins from pyrazine-alkynes and sulfur

The synthesis of a novel family of pentathiepino-pyrrolo[1,2-a]pyrazine derivatives is reported. These compounds are formed by the reaction of alkynyl-substituted heterocyclic precursors with elemental sulfur in the presence of molybdenum oxo bis-tetrasulfide under very mild conditions.

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More research is needed about 3-Phenylquinoxaline-5-carboxylic acid

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4-bicyclically substituted dihydropyridines and their use in medicaments

The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) STR1 in which R1 to R5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

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Quinoxaline – Wikipedia,
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