Electric Literature of 63810-80-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.63810-80-0, Name is 2,3-Dichloro-6,7-dimethylquinoxaline, molecular formula is C10H8Cl2N2. In a article£¬once mentioned of 63810-80-0
Design, synthesis, and biological evaluation of novel 4-alkylamino-1- hydroxymethylimidazo[1,2-a]quinoxalines as adenosine A1 receptor antagonists
The preparation and biological evaluation of a series of 4-alkylamino-1-hydroxymethylimidazo[1,2-a]quinoxalines as adenosine A 1 receptor antagonists are described. 4-Cyclopentylamino-7,8- dichloro-1-hydroxymethylimidazo[1,2-a]quinoxaline shows potent adenosine A 1 receptor inhibitory activity, having Ki = 7 nM. A series of 4-alkylamino-1-hydroxymethylimidazo[1,2-a]quinoxalines have been synthesized and evaluated for their adenosine A1 receptor inhibitory activity in the radioligand binding assays. The compounds were tested for the inhibition percent (IP) and the affinity toward A1AR (Ki) that IP were more than 90% in the nanomolar range. 4-Cyclopentylamino-7,8-dichloro-1- hydroxymethylimidazo[1,2-a]quinoxaline 18 is the most potent compound in this series, having Ki = 7 nM, which is remarkably higher than that of IRFI-165 (Ki = 48). 1-Hydroxymethyl groups of the tricyclic heteroarmatic compounds displayed the potent affinities toward A1AR.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 63810-80-0
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1829 | ChemSpider