Electric Literature of 2213-63-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 2213-63-0, Name is 2,3-Dichloroquinoxaline,introducing its new discovery.
Discovery of novel morpholino-quinoxalines as PI3Kalpha inhibitors by pharmacophore-based screening
A pharmacophore model of PI3Kalpha inhibitors was built using the DiscoveryStudio 2.0 package. Pharmacophore-based screening (PBS) retrieved a series of novel morpholino-quinoxalines as PI3Kalpha inhibitors, as exemplified by 1a (PI3Kalpha IC50: 0.44 muM). All target compounds showed good in vitro cytotoxicity against tested human cell lines. A pharmacophore mapping analysis and docking study indicated that both the morpholino group and the sulfonyl group contributed significantly to the potent PI3Kalpha inhibitory activity and cytotoxicity of the compounds.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 2213-63-0, and how the biochemistry of the body works.Electric Literature of 2213-63-0
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1599 | ChemSpider